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. 2023 Aug 8;101(6):282. doi: 10.1212/WNL.0000000000207718

Reader Response: Association Between Induced Burst Suppression and Clinical Outcomes in Patients With Refractory Status Epilepticus: A 9-Year Cohort Study

Nitin K Sethi 1
PMCID: PMC10424830  PMID: 37550078

I read with interest the study of Fisch et al. and the accompanying editorial on association between induced burst suppression (BS) and treatment outcomes in patients with refractory status epilepticus (RSE).1,2 In the current management of RSE, the goal is to suppress all clinical and electrographic seizures by achieving BS. The study highlights that EEG BS may not be the appropriate treatment target for all patients in RSE. We need to tailor our treatment to each specific patient. In my experience, a “lighter” degree of EEG suppression—while associated with breakthrough seizures—is devoid of the complications attributed to attaining BS records and achieves a favorable clinical outcome in some patients. Treat the patient, not the continuous EEG.

Footnotes

Author disclosures are available upon request (journal@neurology.org).

References

  • 1.Fisch U, Jünger AL, Baumann SM, et al. Association between induced burst suppression and clinical outcomes in patients with refractory status epilepticus: a 9-year cohort study. Neurology. 2023;100(19):e1955-e1966. doi: 10.1212/WNL.0000000000207129 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Young GB, Drislane FW. Aiming for burst suppression in treating refractory status epilepticus: probably not. Neurology. 2023;100(19):889-890. doi: 10.1212/WNL.0000000000207290 [DOI] [PubMed] [Google Scholar]

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