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. 1976 Sep;60(9):645–651. doi: 10.1136/bjo.60.9.645

Internuclear ophthalmoplegia. An electro-oculographic study of peak angular saccadic velocities.

A C Bird, J Leech
PMCID: PMC1042785  PMID: 990235

Abstract

Peak angular saccadic velocities were measured during 30 degrees saccades in 18 patients with internuclear ophthalmoplegia who had full or nearly full adduction range, and 25 normal subjects. The following observations were made: 1. In the normal group adduction velocities were significantly faster than abduction velocities and centring movements were faster than decentring movements. 2. In patients with internuclear ophthalmoplegia adduction movements were significantly slower than in normal subjects and were significantly slower than abduction velocities. 3. Abduction velocities in patients with internuclear ophthalmoplegia were significantly slower than abduction velocities in normal subjects. It was concluded that measurements of peak angular velocities during saccades may be useful in detecting internuclear ophthalmoplegia or confirming the presence of suspected internuclear ophthalmoplegia. Slow abduction suggests that many patients with internuclear ophthalmoplegia (60 per cent in this series) have lesions affecting the supranuclear pathways subserving horizontal conjugate gaze.

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Selected References

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  1. BENDER M. B., WEINSTEIN E. A. The syndrome of the median longitudinal fasciculus. Res Publ Assoc Res Nerv Ment Dis. 1950;28:414–420. [PubMed] [Google Scholar]
  2. Baker R., Highstein S. M. Physiological identification of interneurons and motoneurons in the abducens nucleus. Brain Res. 1975 Jun 27;91(2):292–298. doi: 10.1016/0006-8993(75)90551-x. [DOI] [PubMed] [Google Scholar]
  3. Bird A. C., Sanders M. D. Defects in supranuclear control of horizontal eye movements. Trans Ophthalmol Soc U K. 1970;90:417–432. [PubMed] [Google Scholar]
  4. CARPENTER M. B., McMASTERS R. E. Disturbances of conjugate horizontal eye movements in the monkey. II. Physiological effects and anatomical degeneration resulting from lesions in the medical longitudinal fasciculus. Arch Neurol. 1963 Apr;8:347–368. doi: 10.1001/archneur.1963.00460040017001. [DOI] [PubMed] [Google Scholar]
  5. CHRISTOFF N., ANDERSON P. J., NATHANSON M., BENDER M. B. Problems in anatomic analysis of lesions of the median longitudinal fasciculous. Arch Neurol. 1960 Mar;2:293–304. doi: 10.1001/archneur.1960.03840090057007. [DOI] [PubMed] [Google Scholar]
  6. Cogan D. G. Internuclear ophthalmoplegia, typical and atypical. Arch Ophthalmol. 1970 Nov;84(5):583–589. doi: 10.1001/archopht.1970.00990040585005. [DOI] [PubMed] [Google Scholar]
  7. Cook G., Stark L., Zuber B. L. Horizontal eye movements studied with the on-line computer. Arch Ophthalmol. 1966 Oct;76(4):589–595. doi: 10.1001/archopht.1966.03850010591020. [DOI] [PubMed] [Google Scholar]
  8. Dell'Osso L. F., Robinson D. A., Daroff R. B. Optokinetic asymmetry in internuclear ophthalmoplegia. Arch Neurol. 1974 Aug;31(2):138–139. doi: 10.1001/archneur.1974.00490380086012. [DOI] [PubMed] [Google Scholar]
  9. Fisher C. M. Some neuro-ophthalmological observations. J Neurol Neurosurg Psychiatry. 1967 Oct;30(5):383–392. doi: 10.1136/jnnp.30.5.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Fricker S. J. Dynamic measurements of horizontal eye motion. I. Acceleration and velocity matrices. Invest Ophthalmol. 1971 Sep;10(9):724–732. [PubMed] [Google Scholar]
  11. Fuchs A. F., Luschei E. S. Firing patterns of abducens neurons of alert monkeys in relationship to horizontal eye movement. J Neurophysiol. 1970 May;33(3):382–392. doi: 10.1152/jn.1970.33.3.382. [DOI] [PubMed] [Google Scholar]
  12. HALLPIKE C. S., HOOD J. D., TRINDER E. Some observations on the technical and clinical problems of electro-nystagmography. Confin Neurol. 1960;20:232–240. doi: 10.1159/000104933. [DOI] [PubMed] [Google Scholar]
  13. Holmes G. PALSIES OF THE CONJUGATE OCULAR MOVEMENTS. Br J Ophthalmol. 1921 Jun;5(6):241–250. doi: 10.1136/bjo.5.6.241. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kupfer C., Cogan D. G. Unilateral internuclear ophthalmoplegia. A clinicopathological case report. Arch Ophthalmol. 1966 Apr;75(4):484–489. doi: 10.1001/archopht.1966.00970050486008. [DOI] [PubMed] [Google Scholar]
  15. Loeffler J. D., Hoyt W. F., Slatt B. Motor excitation and inhibition in internuclear palsy. An electromyographic study. Arch Neurol. 1966 Dec;15(6):664–671. doi: 10.1001/archneur.1966.00470180104012. [DOI] [PubMed] [Google Scholar]
  16. McDonald W. I., Sears T. A. The effects of experimental demyelination on conduction in the central nervous system. Brain. 1970;93(3):583–598. doi: 10.1093/brain/93.3.583. [DOI] [PubMed] [Google Scholar]
  17. Metz H. S., Scott A. B., O'Meara D., Stewart H. L. Ocular saccades in lateral rectus palsy. Arch Ophthalmol. 1970 Oct;84(4):453–460. doi: 10.1001/archopht.1970.00990040455010. [DOI] [PubMed] [Google Scholar]
  18. RASHBASS C. The relationship between saccadic and smooth tracking eye movements. J Physiol. 1961 Dec;159:326–338. doi: 10.1113/jphysiol.1961.sp006811. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rothstein T. L., Alvord E. C., Jr Posterior internuclear ophthalmoplegia. A clinicopathological study. Arch Neurol. 1971 Mar;24(3):191–202. doi: 10.1001/archneur.1971.00480330019001. [DOI] [PubMed] [Google Scholar]
  20. SMITH J. L., DAVID N. J. INTERNUCLEAR OPHTHALMOPLEGIA. TWO NEW CLINICAL SIGNS. Neurology. 1964 Apr;14:307–309. doi: 10.1212/wnl.14.4.307. [DOI] [PubMed] [Google Scholar]
  21. Starr A. A disorder of rapid eye movements in Huntington's chorea. Brain. 1967 Sep;90(3):545–564. doi: 10.1093/brain/90.3.545. [DOI] [PubMed] [Google Scholar]
  22. WESTHEIMER G. Mechanism of saccadic eye movements. AMA Arch Ophthalmol. 1954 Nov;52(5):710–724. doi: 10.1001/archopht.1954.00920050716006. [DOI] [PubMed] [Google Scholar]
  23. Weber R. B., Daroff R. B. The metrics of horizontal saccadic eye movements in normal humans. Vision Res. 1971 Sep;11(9):921–928. doi: 10.1016/0042-6989(71)90212-4. [DOI] [PubMed] [Google Scholar]

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