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Schematic diagram of circANAPC7 suppressed tumor growth and muscle wasting through PHLPP2–AKT–TGF-β signaling axis in pancreatic cancer. This study identified circANAPC7 as a novel tumor suppressor, which functions through the CREB–miR-373–PHLPP2 axis, leading to AKT dephosphorylation and cyclin D1 and TGF-β down-regulation to suppress tumor progression in pancreatic cancer.
