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. 1978 Jan;62(1):53–61. doi: 10.1136/bjo.62.1.53

Histology of spheroidal degeneration of the cornea in Labrador.

G J Johnson, M Overall
PMCID: PMC1043136  PMID: 629911

Abstract

Nine specimens of the corneas of patients from Labrador and Northern Newfoundland affected by spheroidal degeneration (climatic droplet keratopathy) have been examined microscopically. Histochemical stains confirmed studies of similar corneal degenerations from other geographical areas that the droplets contain a protein which does not have all the characteristic properties of elastic tissue. Staining compatible in some instances with fibrin and "fibrinoid" was found. By immunoperoxidase techniques the droplets were located in the zones of greatest concentration of various plasma constituents, especially albumin and immunoglobulins G and A. Reasons are given why the abnormal deposits are not thought to be derived directly from corneal collagen. It is suggested that some of the plasma proteins, which are known to be diffusing through the cornea from the limbal vessels under normal conditions are acted upon by the ultraviolet light reflected from the ice of Labrador and degraded so that they accumulate in the superficial stroma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allansmith M. R., Whitney C. R., McClellan B. H., Newman L. P. Immunoglobulins in the human eye. Location, type, and amount. Arch Ophthalmol. 1973 Jan;89(1):36–45. doi: 10.1001/archopht.1973.01000040038010. [DOI] [PubMed] [Google Scholar]
  2. Brownstein S., Rodrigues M. M., Fine B. S., Albert E. N. A histochemical, fluorescent, and electron microscopic examination. Am J Ophthalmol. 1973 May;75(5):799–809. [PubMed] [Google Scholar]
  3. Burns J. Background staining and sensitivity of the unlabelled antibody-enzyme (PAP) method. Comparison with the peroxidase labelled antibody sandwich method using formalin fixed paraffin embedded material. Histochemistry. 1975 Jun 5;43(3):291–294. doi: 10.1007/BF00499711. [DOI] [PubMed] [Google Scholar]
  4. Christensen G. R. Proteinaceous corneal degeneration. A histochemical study. Arch Ophthalmol. 1973 Jan;89(1):30–32. doi: 10.1001/archopht.1973.01000040032008. [DOI] [PubMed] [Google Scholar]
  5. Cursino J. W., Fine B. S. A histologic study of calcific and noncalcific band keratopathies. Am J Ophthalmol. 1976 Sep;82(3):395–404. doi: 10.1016/0002-9394(76)90488-8. [DOI] [PubMed] [Google Scholar]
  6. D'Alena P., Wood I. S. Labrador keratopathy. A microscopic study. Am J Ophthalmol. 1972 Sep;74(3):430–435. doi: 10.1016/0002-9394(72)90902-6. [DOI] [PubMed] [Google Scholar]
  7. ETZINE S., KAUFMANN J. C. BAND-SHAPED NODULAR DYSTROPHY OF THE CORNEA. Am J Ophthalmol. 1964 May;57:760–763. doi: 10.1016/0002-9394(64)92222-6. [DOI] [PubMed] [Google Scholar]
  8. FREEDMAN A. LABRADOR KERATOPATHY. Arch Ophthalmol. 1965 Aug;74:198–202. doi: 10.1001/archopht.1965.00970040200013. [DOI] [PubMed] [Google Scholar]
  9. Fraunfelder F. T., Hanna C., Parker J. M. Spheroid degeneration of the cornea and conjunctiva. 1. Clinical course and characteristics. Am J Ophthalmol. 1972 Nov;74(5):821–828. doi: 10.1016/0002-9394(72)91202-0. [DOI] [PubMed] [Google Scholar]
  10. Freedman A. Climatic droplet keratopathy. I. Clinical aspects. Arch Ophthalmol. 1973 Mar;89(3):193–197. doi: 10.1001/archopht.1973.01000040195006. [DOI] [PubMed] [Google Scholar]
  11. Freedman A. Labrador keratopathy and related diseases. Can J Ophthalmol. 1973 Apr;8(2):286–290. [PubMed] [Google Scholar]
  12. GILLMAN T., PENN J., BRONKS D., ROUX M. Abnormal elastic fibers; appearance in cutaneous carcinoma, irradiation injuries, and arterial and other degenerative connective tissue lesions in man. AMA Arch Pathol. 1955 Jun;59(6):733–749. [PubMed] [Google Scholar]
  13. Garner A., Fraunfelder F. T., Barras T. C., Hinzpeter E. N. Spheroidal degeneration of cornea and conjunctiva. Br J Ophthalmol. 1976 Jun;60(6):473–478. doi: 10.1136/bjo.60.6.473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Garner A. Keratinoid corneal degeneration. Br J Ophthalmol. 1970 Dec;54(12):769–780. doi: 10.1136/bjo.54.12.769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Garner A., Morgan G., Tripathi R. C. Climate dropley keratopathy. II. Pathologic findings. Arch Ophthalmol. 1973 Mar;89(3):198–204. doi: 10.1001/archopht.1973.01000040200007. [DOI] [PubMed] [Google Scholar]
  16. Gillan J. G. The cornea in Canada's Northland. Can J Ophthalmol. 1970 Apr;5(2):146–151. [PubMed] [Google Scholar]
  17. Hanna C., Fraunfelder F. T. Spheroid degeneration of the cornea and conjunctiva. 2. Pathology. Am J Ophthalmol. 1972 Nov;74(5):829–839. doi: 10.1016/0002-9394(72)91203-2. [DOI] [PubMed] [Google Scholar]
  18. Johnson G. J., Ghosh M. Labrador keratopathy: clinical and pathological findings. Can J Ophthalmol. 1975 Apr;10(2):119–135. [PubMed] [Google Scholar]
  19. Klintworth G. K. Chronic actinic keratopathy--a condition associated with conjunctival elastosis (pingueculae) and typified by characteristic extracellular concretions. Am J Pathol. 1972 May;67(2):327–348. [PMC free article] [PubMed] [Google Scholar]
  20. LENDRUM A. C., FRASER D. S., SLIDDERS W., HENDERSON R. Studies on the character and staining of fibrin. J Clin Pathol. 1962 Sep;15:401–413. doi: 10.1136/jcp.15.5.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Lian J. B., Morris S., Faris B., Albright J., Franzblau C. The effects of acetic acid and pepsin on the crosslinkages and ultrastructure of corneal collagen. Biochim Biophys Acta. 1973 Nov 11;328(1):193–204. doi: 10.1016/0005-2795(73)90345-0. [DOI] [PubMed] [Google Scholar]
  22. MACCONAILL M. A., GURR E. THE HISTOLOGICAL PROPERTIES OF RHODANILE BLUE. Ir J Med Sci. 1964 Jun;462:243–250. doi: 10.1007/BF02945784. [DOI] [PubMed] [Google Scholar]
  23. Maurice D. M., Watson P. G. The distribution and movement of serum albumin in the cornea. Exp Eye Res. 1965 Dec;4(4):355–363. doi: 10.1016/s0014-4835(65)80052-5. [DOI] [PubMed] [Google Scholar]
  24. Rodrigues M. M., Laibson P. R., Weinreb S. Corneal elastosis. Appearance of band-like keratopathy and spheroidal degeneration. Arch Ophthalmol. 1975 Feb;93(2):111–114. doi: 10.1001/archopht.1975.01010020117003. [DOI] [PubMed] [Google Scholar]
  25. Stock E. L., Aronson S. B. Corneal immune globulin distribution. Arch Ophthalmol. 1970 Sep;84(3):355–359. doi: 10.1001/archopht.1970.00990040357016. [DOI] [PubMed] [Google Scholar]
  26. Wyatt H. T. Corneal disease in the Canadian North. Can J Ophthalmol. 1973 Apr;8(2):298–305. [PubMed] [Google Scholar]
  27. Young J. D., Finlay R. D. Primary spheroidal degeneration of the cornea in Labrador and northern Newfoundland. Am J Ophthalmol. 1975 Jan;79(1):129–134. doi: 10.1016/0002-9394(75)90470-5. [DOI] [PubMed] [Google Scholar]

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