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. 1978 Sep;62(9):660–662. doi: 10.1136/bjo.62.9.660

Penetration of tobramycin sulphate into the human eye.

A Petounis, G Papapanos, C Karageorgiou-Makromihelaki
PMCID: PMC1043314  PMID: 708683

Abstract

Tobramycin sulphate, a new aminoglycoside antibiotic, was injected intramuscularly (80 and 100 mg) and subconjunctivally (10 mg) into patients, and the concentrations of the drug in serum and aqueous humour were determined 1 hour after the injection by an agar wall diffusion plate method. The intramuscular administration of tobramycin produced insignificant and non-inhibitory concentrations in the aqueous humour, while therapeutically effective levels of the antibiotic appeared in the aqueous after subconjunctival administrationof tobramycin (mean: 18.9 microgram/ml). These data suggest that tobramycin sulphate may be of value in the treatment of ocular infections.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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