Table 2.
Antibiotic MIC for daptomycin-nonsusceptible E. faecium isolate R497 in 96-h SEV samplesa
| SEV model regimen | Antibiotic MIC (μg/mL)a |
|||||
|---|---|---|---|---|---|---|
| Daptomycin | Ceftaroline | Ampicillin | Linezolid | Minocycline | Vancomycin | |
| Baseline | 16 | 128 | 256 | 4 | 16 | 2 |
| Growth control | ||||||
| DAP | ||||||
| No phage | 16 | 128 | 256 | 4 | 16 | 2 |
| NV-497 | ||||||
| NV-503-01 | ||||||
| NV-497–NV-503-01 | ||||||
| CPT | ||||||
| No phage | 16 | 128 | 256 | 4 | 16 | 2 |
| NV-497 | ||||||
| NV-503-01 | ||||||
| NV-497–NV-503-01 | ||||||
| DAP-CPT | ||||||
| No phage | 16 | 128 | 256 | 4 | 16 | 2 |
| NV-497 | ||||||
| NV-503-01 | ||||||
| NV-497–NV-503-01 | 4 | |||||
a
SEV, simulated endocardial vegetation; DAP, daptomycin; CPT, ceftaroline.