Appendix 1—table 2. Comparison of recent computational models for plasticity highlighting the experimental conditions implemented and the experiments in the hippocampus and cortex they reproduce.

See Appendix 1—table 3 for additional details on experimental conditions of experimental works.

Model	Graupner and Brunel, 2012	Ebner et al., 2019	Jędrzejewska-Szmek et al., 2017	Inglebert et al., 2020	Chindemi et al., 2022	This paper
Model framework	Extension of Shouval et al., 2002	Extension of Clopath et al., 2010 and modified from Hay et al., 2011	Modified from Evans et al., 2013	Extension of Graupner and Brunel, 2012	Extension of Graupner and Brunel, 2012
Parameter
Temperature	Absent	Absent	Temperature corrected ion channels (but not receptors)	No temperature control needed (experiments covered are at 30° C)	Only in the GHK equation	Temperature is selectable on the dendritic spine level for ion channels, receptor and the calcium cascade
Development	Absent	Absent	Absent	Absent	Absent	Age is selectable and implemented by GABAr and NMDAr switch and BaP maturation
aCSF	Absent	Absent	Absent	Phenomenological changes in pre and post amplitudes to mimic extracellular calcium effects	In vivo or in vitro changes for release probability, calcium reversal potential on NMDAr-induced calcium influx	External Ca and Mg are selectable and affect release probability, reversal potential, NMDAr and VGCCs calcium current driving force
Plasticity experiments (quant. comparisons only)
Sjöström et al., 2001	X	X			X
Wittenberg and Wang, 2006	X					X
Wang et al., 2005	X
Sjöström and Häusser, 2006	X	X			X
Nevian and Sakmann, 2006		X
Letzkus et al., 2006		X
Weber et al., 2016		X
Fino et al., 2010			X
Pawlak and Kerr, 2008			X
Shen et al., 2008			X
Inglebert et al., 2020				X		X
Markram et al., 1997					X
Rodríguez-Moreno and Paulsen, 2008					X
Egger et al., 1999					X
Tigaret et al., 2016						X
Dudek and Bear, 1992						X
Dudek and Bear, 1993						X
Mizuno et al., 2001						X
Meredith et al., 2003						X
O’Connor et al., 2005 (not included due to space)						X
Bittner et al., 2017 (not included due to space)						X