Table 2. Parameter values for the presynaptic model.

Our model does not implement a larger pool of ∼ 180 vesicles (CA3-CA1 hippocampus) sometimes named ‘reserve pool’ (Südhof, 2000) or ‘resting pool’ (Alabi and Tsien, 2012). Furthermore, what we term the ‘reserve pool’ in our model is sometimes called the ‘recycling pool’ in other studies, for example Rizzoli and Betz, 2005; Alabi and Tsien, 2012.

Name	Value	Reference
Vesicle release model (stochastic part)
Initial number of vesicles at D	$D_0=25$	5–20 (Rizzoli and Betz, 2005; Alabi and Tsien, 2012)
Initial number of vesicles at R	$R_0=30$	17–20 vesicles (Alabi and Tsien, 2012)
Time constant R→ D (D recycling)	${\tau }_D=5s$	1 s (Rizzoli and Betz, 2005)
time constant D → R (R mixing)	${\displaystyle {\tau }_R=45s}$	20 s (when depleted) to 5 min (hypertonic shock) (Rizzoli and Betz, 2005; Pyle et al., 2000)
Time constant 1→ R (R recycling)	${\tau }_R^{ref}=40s$	20–30 s (Rizzoli and Betz, 2005)
Release probability half-activation curve	$h$	see Equation 1
Release probability sigmoid slope	$s=2$	fixed for all [Ca2+]o
Vesicle release model (deterministic part)
${\displaystyle C{a}_{pre}}$ attenuation recovery	${\displaystyle {\tau }_{pre}=0.02s}$	50-500 ms with dye (Maravall et al., 2000) therefore < 50 to 500 ms without dye
Deterministic jump attenuation recovery	${\tau }_{rec}=20s$	∼20 s (Rizzoli and Betz, 2005)
Deterministic jump attenuation fraction	${\delta }_{ca}=0.0004$	Forsythe et al., 1998