Table 5. Parameter values for the AMPAr Markov chain and glutamate release affecting NMDAr, AMPAr.

Properties of GABA release are the same as those for glutamate.

Name	Value	Reference
Glutamate parameters
Duration of glutamate in the cleft	$gl{u}_{width}=0.001s$	Spruston et al., 1995
Concentration of glutamate in the cleft	$gl{u}_{amp}={10}^3\mu M$	Spruston et al., 1995
Glutamate variability (gamma distribution $\mathrm{\Gamma }$)	$gl{u}_{cv}=\mathrm{\Gamma }(1/{0.5}^2,{0.5}^2)$	Liu et al., 1999
Glutamate signal	$Glu$	$g\mathbf{}l\mathbf{}{u}_{c\mathbf{}v}\mathrm{\cdot }g\mathbf{}l\mathbf{}{u}_{a\mathbf{}m\mathbf{}p}$ for AMPAr, NMDAr and copied to GABA neurotransmitter
AMPAr parameters
Number of AMPArs	$N_{AMPA}$=120	Bartol et al., 2015
Reversal potential	$Ere{v}_{AMPA}=0mV$	Bartol et al., 2015
Subconductance O2	${\gamma }_{A2}=0.0155nS$	$0.0163nS$ (Coombs et al., 2017)
Subconductance O3	${\gamma }_{A3}=0.026nS$	$0.0287nS$ (Coombs et al., 2017)
Subconductance O4	${\gamma }_{A4}=0.0365nS$	$0.0378nS$ (Coombs et al., 2017)
glu binding	$k_1=16\mu M^{-1}{s}^{-1}$	Robert and Howe, 2003
glu unbinding 1	$k_{-1}=7400s^{-1}$	Robert and Howe, 2003
glu unbinding 2	$k_{-2}=0.41s^{-1}$	Robert and Howe, 2003
Closing	$\alpha =2600s^{-1}$	Robert and Howe, 2003
Opening	$\beta =9600s^{-1}$	Robert and Howe, 2003
Desensitisation 1	${\delta }_1=1500s^{-1}$	Robert and Howe, 2003
Desensitisation 2	${\delta }_2=170s^{-1}$	Robert and Howe, 2003
Desensitisation 3	${\delta }_0=0.003s^{-1}$	Robert and Howe, 2003
Re-desensitisation 1	${\gamma }_1=9.1s^{-1}$	Robert and Howe, 2003
Re-desensitisation 2	${\gamma }_2=42s^{-1}$	Robert and Howe, 2003
Re-desensitisation 3	${\gamma }_0=0.83s^{-1}$	Robert and Howe, 2003