Table 7. NMDAr parameters.

The existing model of NMDAr (GluN2A) was adapted to obtain the NMDAr (GluN2B) model. The decay time of NMDAr (GluN2B) was fitted to match decay time in Iacobucci and Popescu, 2018 and the temperature dependence uses the EPSP decay time from Korinek et al., 2010.

Name	Value	Reference
NMDAr (GluN2A)
Glutamate binding	$k_a=34\mu M^{-1}{s}^{-1}$	Popescu et al., 2004
Glutamate binding	$k_b=17\mu M^{-1}{s}^{-1}$	Popescu et al., 2004
Forward rate	$k_c=127s^{-1}$	Popescu et al., 2004
Forward rate	$k_d=580s^{-1}$	Popescu et al., 2004
Opening rate	$k_e=2508s^{-1}$	Popescu et al., 2004
Opening rate	$k_f=3449s^{-1}$	Popescu et al., 2004
Closing rate	$k_{-f}=662s^{-1}$	Popescu et al., 2004
Closing rate	$k_{-e}=2167s^{-1}$	Popescu et al., 2004
Backward rate	$k_{-d}=2610s^{-1}$	Popescu et al., 2004
Backward rate	$k_{-c}=161s^{-1}$	Popescu et al., 2004
Glutamate unbinding	$k_{-b}=120s^{-1}$	Popescu et al., 2004
Glutamate unbinding	$k_{-a}=60s^{-1}$	Popescu et al., 2004
NMDAr (GluN2B)
Glutamate binding	$s_b=0.25k_b$	adapted from GluN2A (Popescu et al., 2004; Iacobucci and Popescu, 2018)
Glutamate binding	$s_c=0.25k_c$	adapted from GluN2A (Popescu et al., 2004; Iacobucci and Popescu, 2018)
Forward rate	$s_c=0.25k_c$	adapted from GluN2A (Popescu et al., 2004; Iacobucci and Popescu, 2018)
Forward rate	$s_d=0.25k_d$	adapted from GluN2A (Popescu et al., 2004; Iacobucci and Popescu, 2018)
Opening rate	$s_e=0.25k_e$	adapted from GluN2A (Popescu et al., 2004; Iacobucci and Popescu, 2018)
Opening rate	$s_f=0.25k_f$	adapted from GluN2A (Popescu et al., 2004; Iacobucci and Popescu, 2018)
Closing rate	$s_{-f}=0.23k_{-f}$	adapted from GluN2A (Popescu et al., 2004; Iacobucci and Popescu, 2018)
Closing rate	$s_{-e}=0.23k_{-e}$	adapted from GluN2A (Popescu et al., 2004; Iacobucci and Popescu, 2018)
Backward rate	$s_{-d}=0.23k_{-d}$	adapted from GluN2A (Popescu et al., 2004; Iacobucci and Popescu, 2018)
Backward rate	$s_{-c}=0.23k_{-c}$	adapted from GluN2A (Popescu et al., 2004; Iacobucci and Popescu, 2018)
Glutamate unbinding	$s_{-b}=0.23k_{-b}$	adapted from GluN2A (Popescu et al., 2004; Iacobucci and Popescu, 2018)
Glutamate unbinding	$s_{-a}=0.23k_{-a}$	adapted from GluN2A (Popescu et al., 2004; Iacobucci and Popescu, 2018)
Other parameters
Total number of NMDAr	$N_{NMDA}=15$	5–30 (Spruston et al., 1995; Bartol et al., 2015; Nimchinsky et al., 2004)
Distribution of GluN2A and GluN2B	defined by ${\displaystyle r_{age}}$	fitted from Sinclair et al., 2016, see Figure 13b and e
NMDAr conductance depending on calcium	${\gamma }_{NMDA}$	fitted from Maki and Popescu, 2014, see Figure 13c
NMDAr reversal potential	Erev ${}_{NMDA}=0mV$	Destexhe et al., 1994
Fraction of calcium carried by NMDAr	$f_{Ca}=0.1$	Griffith et al., 2016