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. 2023 Aug 22;12:e82210. doi: 10.7554/eLife.82210

Figure 4. Genes involved in ether lipid biosynthesis are required for lifespan extension in multiple longevity paradigms.

(A–C) isp-1, raga-1, and eat-2 mutants display extended lifespan relative to wild-type animals that is dependent upon the three members of the ether lipid biosynthetic pathway. Results are representative of three biological replicates. **, p<0.01; ***, p<0.001; ****, p<0.0001 by log-rank analysis. See also Figure 4—figure supplement 1 and Supplementary file 1 for tabular survival data and biological replicates.

Figure 4.

Figure 4—figure supplement 1. Ether lipid biosynthetic genes are not necessary for daf-2-dependent lifespan extension.

Figure 4—figure supplement 1.

daf-2 mutants display extended lifespan relative to wild-type animals. RNA interference (RNAi) knockdown of fard-1, acl-7, and ads-1 does not impact lifespan extension in these mutants. ns, p>0.05; ***, p<0.001 by log-rank analysis. For tabular survival data and biological replicates, see also Supplementary file 1.