Abstract
Serum concentrations of tinidazole and metronidazole have been measured in healthy female volunteers who received a single dose of 2 g. of each drug in a cross-over study. Bioassays against T. vaginalis showed that metronidazole achieved higher peak concentrations (mean 81 mug./ml.) than did tinidazole (mean 67 mug./ml.), while assays for unchanged drug showed higher peak concentrations of tinidazole )mean 51 mug./ml;) than of metronidazole (mean 40 mug./ml9). This discrepancy is probably due to the presence in the serum of active metabolites of metronidazole. The longer half-life of tinidazole led to significantly higher serum concentrations (by bioassay and chemical assay) of tinidazole than of metronidazole from 6 hrs onwards.
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- Csonka G. W. Trichomonal vaginitis treated with one dose of metronidazole. Br J Vener Dis. 1971 Dec;47(6):456–458. doi: 10.1136/sti.47.6.456. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Forsgren A., Wallin J. Trinidazole--a new preparation for Trichomonas vaginalis infections. I. Laboratory evaluation. Br J Vener Dis. 1974 Apr;50(2):146–147. doi: 10.1136/sti.50.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Howes H. L., Jr, Lynch J. E., Kivlin J. L. Tinidazole, a new antiprotozoal agent: Effect on Trichomonas and other protozoa. Antimicrob Agents Chemother (Bethesda) 1969;9:261–266. [PubMed] [Google Scholar]
- Rösemann G. W., Vaughan J. Treatment of trichomoniasis in the female with a single dose of tinidazole. S Afr Med J. 1973 Jul 21;47(28):1222–1224. [PubMed] [Google Scholar]
- Stambaugh J. E., Feo L. G., Manthei R. W. The isolation and identification of the urinary oxidative metabolites of metronidazole in man. J Pharmacol Exp Ther. 1968 Jun;161(2):373–381. [PubMed] [Google Scholar]
- Taylor J. A., Jr, Migliardi J. R., Von Wittenau M. S. Tinidazole and metronidazole pharmocokinetics in man and mouse. Antimicrob Agents Chemother (Bethesda) 1969;9:267–270. [PubMed] [Google Scholar]
- Wallin J., Forsgren A. Tinidazole--a new preparation for T. vaginalis infections. II. Clinical evaluation of treatment with a single oral dose. Br J Vener Dis. 1974 Apr;50(2):148–150. doi: 10.1136/sti.50.2.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Welling P. G., Monro A. M. The pharmacokinetics of metronidazole and tinidazole in man. Arzneimittelforschung. 1972 Dec;22(12):2128–2132. [PubMed] [Google Scholar]