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. 1975 Apr;51(2):130–133. doi: 10.1136/sti.51.2.130

Neutral red with photoinactivation in the treatment of herpes genitalis.

A P Roome, A E Tinkler, A L Hilton, D G Montefiore, D Waller
PMCID: PMC1045129  PMID: 165862

Abstract

A clinical trial was undertaken to compare the efficacy of neutral red photodynamic inactivation treatment of genital herpes infections with that of a non-photoactive dye, phenol red, as a control. In a series of nineteen patients with virologically proven herpes genitalis who were adequately followed, eleven were treated with neutral red, and eight with phenol red; no difference in response to therapy was found between the two groups, and it is concluded that under the conditions of this trial neutral red with photoinactivation was not effective in the treatment of acute genital herpes infections. Approximately 75 per cent. of those with vulval lesions also had concurrent cervical infection, so that an effective topical treatment would need to be applicable to both anatomical sites.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chesterman J. T. Aetiology of Pancreatic Apoplexy. Br Med J. 1945 Oct 6;2(4422):461–461. doi: 10.1136/bmj.2.4422.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Friedrich E. G., Jr Relief for Herpes vulvitis. Obstet Gynecol. 1973 Jan;41(1):74–77. [PubMed] [Google Scholar]
  3. Kaufman R. H., Gardner H. L., Brown D., Wallis C., Rawls W. E., Melnick J. L. Herpes genitalis treated by photodynamic inactivation of virus. Am J Obstet Gynecol. 1973 Dec 15;117(8):1144–1146. doi: 10.1016/0002-9378(73)90768-0. [DOI] [PubMed] [Google Scholar]
  4. Kaufman R. H., Gardner H. L., Rawls W. E., Dixon R. E., Young R. L. Clinical features of herpes genitalis. Cancer Res. 1973 Jun;33(6):1446–1451. [PubMed] [Google Scholar]
  5. Moore C., Wallis C., Melnick J. L., Kuns M. D. Photodynamic treatment of herpes keratitis. Infect Immun. 1972 Feb;5(2):169–171. doi: 10.1128/iai.5.2.169-171.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Nahmias A. J., Josey W. E., Naib Z. M., Luce C. F., Duffey A. Antibodies to Herpesvirus hominis types 1 and 2 in humans. I. Patients with genital herpetic infections. Am J Epidemiol. 1970 Jun;91(6):539–546. doi: 10.1093/oxfordjournals.aje.a121165. [DOI] [PubMed] [Google Scholar]
  7. Ng A. B., Reagan J. W., Yen S. S. Hepres genitalis; clinical and cytopathologic experience with 256 patients. Obstet Gynecol. 1970 Oct;36(4):645–651. [PubMed] [Google Scholar]
  8. Rawls W. E., Gardner H. L., Flanders R. W., Lowry S. P., Kaufman R. H., Melnick J. L. Genital herpes in two social groups. Am J Obstet Gynecol. 1971 Jul 1;110(5):682–689. doi: 10.1016/0002-9378(71)90254-7. [DOI] [PubMed] [Google Scholar]
  9. Smith I. W., Peutherer J. F., Robertson D. H. Characterization of genital strains of Herpesvirus hominis. Br J Vener Dis. 1973 Aug;49(4):385–390. doi: 10.1136/sti.49.4.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Thomas J. V., Dunlap W. A., Rich A. M. Photodynamic inactivation in the treatment of experimental herpes simplex keratitis. Br J Ophthalmol. 1973 May;57(5):336–338. doi: 10.1136/bjo.57.5.336. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Varnell E. D., Kaufman H. E. Photodynamic inactivation with proflavine: quantitative comparison with iodo-deoxyuridine. Infect Immun. 1973 Apr;7(4):518–519. doi: 10.1128/iai.7.4.518-519.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. WALLIS C., MELNICK J. L. IRREVERSIBLE PHOTOSENSITIZATION OF VIRUSES. Virology. 1964 Aug;23:520–527. doi: 10.1016/0042-6822(64)90236-3. [DOI] [PubMed] [Google Scholar]
  13. Wallis C., Melnick J. L., Kaufman R. H. Herpes genitalis: management--present and predicted. Clin Obstet Gynecol. 1972 Dec;15(4):939–947. doi: 10.1097/00003081-197212000-00008. [DOI] [PubMed] [Google Scholar]

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