Abstract
349 male patients with uncomplicated gonococcal urethritis were treated with a single dose of 300 mg. or 400 mg. minocycline hydrochloride. The lower dose gave a lower failure rate, 3-2 compared with 5-1 per cent., but this difference was not statistically significant. The overall known failure rate of 4-2 per cent. compares most favourably with our previous findings in this area using other drugs of the tetracycline group. The incidence of post-gonococcal urethritis (5-1 per cent.) was also the lowest we have found. The few side-effects reported were comparatively trivial. Because of its high degree of therapeutic efficacy, the relatively lack of side-effects, and the reduced incidence of post-gonococcal urethritis, minocycline hydrochloride should be considered the drug of choice whenever single-dose oral treatment is given in uncomplicated gonorrhoea in men.
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Selected References
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- Duncan W. C., Glicksman J. M., Knox J. M., Holder W. R. Treatment of gonorrhoea with a single oral dose of minocycline. Br J Vener Dis. 1971 Oct;47(5):364–366. doi: 10.1136/sti.47.5.364. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gray R. C., Phillips I., Nicol C. S. Treatment of gonorrhoea with three different antibiotic regimes: doxycycline 300 mg., procaine penicillin plus benzyl penicillin 2.4 m.u., benzyl penicillin 5 m.u. plus probenecid. Br J Vener Dis. 1970 Oct;46(5):401–403. doi: 10.1136/sti.46.5.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Masterton G., Schofield C. B. Doxycycline HCl (Vibramycin) as a single dose oral treatment of gonococcal and nonspecific urethritis in men. Br J Vener Dis. 1972 Apr;48(2):121–125. doi: 10.1136/sti.48.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Masterton G., Schofield C. B., Tait I. B. Triple tetracycline ('Deteclo') as a single dose oral treatment of uncomplicated gonorrhoea in the male. Curr Med Res Opin. 1973;1(4):207–211. doi: 10.1185/03007997309111669. [DOI] [PubMed] [Google Scholar]
- Phillips I., Ridley M., Rimmer D., Lynn R. In-vitro activity of twelve antibacterial agents against Neisseria gonorrhoeae. Lancet. 1970 Feb 7;1(7641):263–265. doi: 10.1016/s0140-6736(70)90635-5. [DOI] [PubMed] [Google Scholar]
- Schofield C. B., Masterton G. Doxycycline HC1 (Vibramycin) syrup as a single-dose oral treatment for uncomplicated urethritis in men. Br J Vener Dis. 1974 Aug;50(4):303–307. doi: 10.1136/sti.50.4.303. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Steigbigel N. H., Reed C. W., Finland M. Susceptibility of common pathogenic bacteria to seven tetracycline antibiotics in vitro. Am J Med Sci. 1968 Mar;255:179–195. doi: 10.1097/00000441-196803000-00005. [DOI] [PubMed] [Google Scholar]
- Thatcher R. W., Pazin G., Domescik G. Gonorrheal urethritis in males treated with a single oral dose of minocycline. Public Health Rep. 1970 Feb;85(2):160–162. [PMC free article] [PubMed] [Google Scholar]