Skip to main content
NCBI home page
The British Journal of Venereal Diseases logoLink to The British Journal of Venereal Diseases
. 1976 Dec;52(6):384–386. doi: 10.1136/sti.52.6.384

Prevalence of multiple antibiotic resistance in Neisseria gonorrhoeae.

D J Platt
PMCID: PMC1045315  PMID: 827327

Abstract

The susceptibility of 100 strains of Neisseria gonorrhoeae to five antimicrobial agents (penicillin, streptomycin, oxytetracycline, sulphamethoxazole, and gentamicin) was examined. Three strains were resistant to each antimicrobial, fourteen exhibited resistance to three or four of the five compounds tested, and 49 were resistant to a single agent, or to pairs of the selected agents. 34 strains were found to be fully sensitive to all of the compounds tested. It is suggested that resistance to gentamicin and sulphamethoxazole may be determined by a multiple resistance gene. The overall frequency of penicillin resistance was found to be 26-5 per cent (MIC greater than 0-06 mug/ml.), suggesting a significant decrease in resistance since 1968.

Full text

PDF
384

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beck A., Fluker J. L., Platt D. J. Neisseria meningitidis in urogenital infection. Br J Vener Dis. 1974 Oct;50(5):367–369. doi: 10.1136/sti.50.5.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brorson J. E., Holmberg I., Nygren B., Seeberg S. Vancomycin-sensitive strains of Neisseria gonorrhoeae. A problem for the diagnostic laboratory. Br J Vener Dis. 1973 Oct;49(5):452–453. doi: 10.1136/sti.49.5.452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CURTIS F. R., WILKINSON A. E. A comparison of the in vitro sensitivity of gonococci to penicillin with the results of treatment. Br J Vener Dis. 1958 Jun;34(2):70–82. doi: 10.1136/sti.34.2.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ericsson H. M., Sherris J. C. Antibiotic sensitivity testing. Report of an international collaborative study. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;217(Suppl):1+–1+. [PubMed] [Google Scholar]
  5. Maier T. W., Beilstein H. R., Zubrzycki L. Antibiotic disk susceptibility tests with Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1974 Mar;5(3):210–216. doi: 10.1128/aac.5.3.210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Maier T. W., Zubrzycki L., Coyle M. B., Chila M., Warner P. Genetic analysis of drug resistance in Neisseria gonorrhoeae: production of increased resistance by the combination of two antibiotic resistance loci. J Bacteriol. 1975 Nov;124(2):834–842. doi: 10.1128/jb.124.2.834-842.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Maier T. W., Zubrzycki L., Coyle M. B. Genetic analysis of drug resistance in Neisseria gonorrhoeae: identification and linkage relationships of loci controlling drug resistance. Antimicrob Agents Chemother. 1975 May;7(5):676–681. doi: 10.1128/aac.7.5.676. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Maness M. J., Sparling P. F. Multiple antibiotic resistance due to a single mutation in Neisseria gonorrhoeae. J Infect Dis. 1973 Sep;128(3):321–330. doi: 10.1093/infdis/128.3.321. [DOI] [PubMed] [Google Scholar]
  9. Nicol C. S., Ridley M., Symonds M. A. The problem of penicillin resistant gonococci. Br J Vener Dis. 1968 Dec;44(4):315–318. doi: 10.1136/sti.44.4.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Phillips I., Ridley M., Rimmer D., Lynn R. In-vitro activity of twelve antibacterial agents against Neisseria gonorrhoeae. Lancet. 1970 Feb 7;1(7641):263–265. doi: 10.1016/s0140-6736(70)90635-5. [DOI] [PubMed] [Google Scholar]
  11. Reyn A. Recent developments in the laboratory diagnosis of gonococcal infections. Bull World Health Organ. 1969;40(2):245–255. [PMC free article] [PubMed] [Google Scholar]
  12. Riddell R. H., Buck A. C. Trimethoprim as an additional selective agent in media for the isolation of N. gonorrhoeae. J Clin Pathol. 1970 Sep;23(6):481–483. doi: 10.1136/jcp.23.6.481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ronald A. R., Eby J., Sherris J. C. Susceptibility of Neisseria gonorrhoeae to penicillin and tetracycline. Antimicrob Agents Chemother (Bethesda) 1968;8:431–434. [PubMed] [Google Scholar]
  14. Sarubbi F. A., Jr, Sparling P. F., Blackman E., Lewis E. Loss of low-level antibiotic resistance in Neisseria gonorrhoeae due to env mutations. J Bacteriol. 1975 Nov;124(2):750–756. doi: 10.1128/jb.124.2.750-756.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sparling P. F., Sarubbi F. A., Jr, Blackman E. Inheritance of low-level resistance to penicillin, tetracycline, and chloramphenicol in Neisseria gonorrhoeae. J Bacteriol. 1975 Nov;124(2):740–749. doi: 10.1128/jb.124.2.740-749.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Stolz E., Zwart H. G., Michel M. F. Activity of eight antimicrobial agents in vitro against N. Gonorrhoeae. Br J Vener Dis. 1975 Aug;51(4):257–264. doi: 10.1136/sti.51.4.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Ward M. E., Watt P. J. The preservation of gonococci in liquid nitrogen. J Clin Pathol. 1971 Mar;24(2):122–123. doi: 10.1136/jcp.24.2.122. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Watko L. P., Brownlow W. J. Antibiotic susceptibility of Neisseria gonorrhoeae isolated in the Western Pacific in 1971. Br J Vener Dis. 1975 Feb;51(1):34–37. doi: 10.1136/sti.51.1.34. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Wigfield A. S., Selkon J. B., Rich G. E. Single-session treatment of uncomplicated gonorrhoea in men, using penicillin combined with cotrimoxazole. Controlled trial comparing four different treatment schedules with observations on antibiotic sensitivities of gonococci and a review of the literature. Br J Vener Dis. 1973 Jun;49(3):277–290. doi: 10.1136/sti.49.3.277. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Venereal Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES