Abstract
A total of 56 cases with warts in which podophyllin treatment was either contraindicated or a failure, were treated with nitrous oxide using a Keymed 500 cryosurgical appliance. Forty-three patients who completed treatment were followed-up for three months. Thirty-seven of these had received applications of podophyllin twice weekly for an average period of three months before cryosurgery. The remaining cases in whom podophyllin was considered to be contraindicated included five with vulval warts (two were pregnant, two were bronchial asthmatics taking oral prednisolone, and one was taking oral clomiphene citrate), and a diabetic patients with penile warts. Thirty-two were cured and 11 relapsed. The latter were re-treated at the end of the follow-up period with two freezing cycles of 45 seconds at an interval of 30 minutes. Seven were cured and the remaining four men who failed to respond belonged to the podophyllin-resistant group and included three with metal warts and one homosexual with anogenital warts. Cryosurgery gave a cumulative success rate of 91%. A single freezing cycle was free from complications but a double freezing cycle was often followed by severe local reaction.
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- Chamberlain M. J., Reynolds A. L., Yeoman W. B. Medical memoranda. Toxic effect of podophyllum application in pregnancy. Br Med J. 1972 Aug 12;3(5823):391–392. doi: 10.1136/bmj.3.5823.391. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Farrant J., Morris G. J. Thermal shock and dilution shock as the causes of freezing injury. Cryobiology. 1973 Jun;10(2):134–140. doi: 10.1016/0011-2240(73)90019-9. [DOI] [PubMed] [Google Scholar]
- Gill W., Da Costa J., Fraser J. The control and predictability of a cryolesion. Cryobiology. 1970 Jan-Feb;6(4):347–353. doi: 10.1016/s0011-2240(70)80089-x. [DOI] [PubMed] [Google Scholar]
- Greenberg J. H., Smith T. L., Katz R. M. Verrucae vulgaris rejection. A preliminary study of contact dermatitis and cellular immunity response. Arch Dermatol. 1973 Apr;107(4):580–582. doi: 10.1001/archderm.107.4.580. [DOI] [PubMed] [Google Scholar]
- LITWIN M. S. FIRST ANNUAL CONFERENCE ON BIOLOGIC EFFECTS OF LASER RADIATION. A SUMMING UP. Fed Proc. 1965 Jan-Feb;24:SUPPL 14–14:177. [PubMed] [Google Scholar]
- LOVELOCK J. E. The denaturation of lipid-protein complexes as a cause of damage by freezing. Proc R Soc Lond B Biol Sci. 1957 Dec 17;147(929):427–433. doi: 10.1098/rspb.1957.0062. [DOI] [PubMed] [Google Scholar]
- Oriel J. D. Natural history of genital warts. Br J Vener Dis. 1971 Feb;47(1):1–13. doi: 10.1136/sti.47.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ostergard D. R., Townsend D. E. The treatment of vulvar condyloma acuminata by cryosurgery. A preliminary report. Cryobiology. 1969 Mar-Apr;5(5):340–342. doi: 10.1016/s0011-2240(69)80463-3. [DOI] [PubMed] [Google Scholar]
- Pyrhönen S., Johansson E. Regression of warts. An immunological study. Lancet. 1975 Mar 15;1(7907):592–596. doi: 10.1016/s0140-6736(75)91880-2. [DOI] [PubMed] [Google Scholar]
- Zacarian S. A., Adham M. I. Cryogenic temperature studies of human skin. Temperature recordings at two millimeter human skin depth following application with liquid nitrogen. J Invest Dermatol. 1967 Jan;48(1):7–10. [PubMed] [Google Scholar]