Abstract
Talampicillin was effective in eradicating the causitive organism in uncomplicated gonorrhoea, with only four treatment failures (1-6%) in 245 patients seen at least once after treatment. Symptoms, such as discharge, were seen in 61 patients at some stage after treatment but 31 of these cases were clear after one or two follow-up visits. The anitbiotic was well tolerated. One patient developed a maculopapular rash, penicillin allergy was reported in two patients, and a generalised itch (possibly penicillin allergy) in one further patient. A total of 241 out of 245 (98%) cases had the urethral gonococcus successfully eradicated with talampicillin. Talampicillin given in single doses appears to be an extremely good choice of antibiotic in the treatment of uncomplicated gonorrhoea in men.
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Selected References
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- Gundersen T., Odegaard K., Gjessing H. C. Treatment of gonorrhoea by one oral dose of ampicillin and probenecid combined. Br J Vener Dis. 1969 Sep;45(3):235–237. doi: 10.1136/sti.45.3.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kvale P. A., Keys T. F., Johnson D. W., Holmes K. K. Single oral dose ampicillin-probenecid treatment of gnorrhea in the male. JAMA. 1971 Mar 1;215(9):1449–1453. [PubMed] [Google Scholar]
- Masterton G., Schofield C. B. Doxycycline HCl (Vibramycin) as a single dose oral treatment of gonococcal and nonspecific urethritis in men. Br J Vener Dis. 1972 Apr;48(2):121–125. doi: 10.1136/sti.48.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Olsen G. A., Lomholt G. Gonorrhoea treated by a combination of probenecid and sodium penicillin G. Br J Vener Dis. 1969 Jun;45(2):144–148. doi: 10.1136/sti.45.2.144. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Price J. D., Fluker J. L. Amoxycillin in the treatment of gonorrhoea. Br J Vener Dis. 1975 Dec;51(6):398–400. doi: 10.1136/sti.51.6.398. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Willcox R. R., Woodcock K. R., Latto D., John J., Redmond A., Parker R. B., Rees G. D., Cobbold R. J. Treatment of gonorrhoea with single oral doses of ampicillin plus probenecid. I. Comparison with procaine penicillin. Br J Vener Dis. 1973 Jun;49(3):263–267. doi: 10.1136/sti.49.3.263. [DOI] [PMC free article] [PubMed] [Google Scholar]