Abstract
Ninety-five men suffering from gonococcal urethritis were treated and observed. Forty-nine developed postgonococcal non-specific urethritis (PGU). Seventeen men were demonstrated to be free from PGU after careful observation; these formed a control group. Chlamydia trachomatis was isolated from urethral material from 26 (53%) of the PGU group but from none of the controls. This difference was highly significant (P less than 0-001). It confirms that C. tachomatis is a pathogen in the urethra. The presence of specific IgM antibody to C. trachomatis in serum from some men developing PGU, from whom that organism was isolated, suggests that the infection was recent in those cases. Ureaplasma urealyticum (T strain mycoplasma) was isolated from urethral material taken from 22 (45%) of the 49 men in the PGU group, and from 12 (71%) of the 17 in the control group. Mycoplasma hominis was isolated from 10 (20%) of the 49 men in the PGU group, and from four (24%) of the 17 men in the control group. Thus, no evidence was obtained that mycoplasmas (U. urealyticum, M. hominis) are patogenic in the urethra.
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Selected References
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- DUNLOP E. M., AL-HUSSAINI M. K., GARLAND J. A., TREHARNE J. D., HARPER I. A., JONES B. R. INFECTION OF URETHRA BY TRIC AGENT IN MEN PRESENTING BECAUSE OF "NON-SPECIFIC" URETHRITIS. Lancet. 1965 May 29;1(7396):1125–1128. doi: 10.1016/s0140-6736(65)91954-9. [DOI] [PubMed] [Google Scholar]
- Dunlop E. M., Vaughan-Jackson J. D., Darougar S. Chlamydial infection. Improved methods of collection of material for culture from the urogenital tract and rectum. Br J Vener Dis. 1972 Dec;48(6):421–424. doi: 10.1136/sti.48.6.421. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dwyer R. S., Treharne J. D., Jones B. R., Herring J. Chlamydial infection. Results of micro-immunofluorescence tests for the detection of type-specific antibody in certain chlamydial infections. Br J Vener Dis. 1972 Dec;48(6):452–459. doi: 10.1136/sti.48.6.452. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hare M. J., Dunlop E. M., Taylor-Robinson D. Mycoplasmas and "non-specific" genital infection. 3. Post-gonococcal urethritis. A prospective study. Br J Vener Dis. 1969 Dec;45(4):282–286. doi: 10.1136/sti.45.4.282. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holmes K. K., Handsfield H. H., Wang S. P., Wentworth B. B., Turck M., Anderson J. B., Alexander E. R. Etiology of nongonococcal urethritis. N Engl J Med. 1975 Jun 5;292(23):1199–1205. doi: 10.1056/NEJM197506052922301. [DOI] [PubMed] [Google Scholar]
- Oriel J. D., Reeve P., Powis P., Miller A., Nicol C. S. Chlamydial infection. Isolation of Chlamydia from patients with non-specific genital infection. Br J Vener Dis. 1972 Dec;48(6):429–436. doi: 10.1136/sti.48.6.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oriel J. D., Reeve P., Thomas B. J., Nicol C. S. Infection with Chlamydia group A in men with urethritis due to Neisseria gonorrhoeae. J Infect Dis. 1975 Apr;131(4):376–382. doi: 10.1093/infdis/131.4.376. [DOI] [PubMed] [Google Scholar]