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. 1978 Feb;54(1):28–35. doi: 10.1136/sti.54.1.28

Epidemiology and treatment of gonorrhoea caused by penicillinase-producing strains in Liverpool.

O P Arya, E Rees, A Percival, C D Alergant, E H Annels, G C Turner
PMCID: PMC1045466  PMID: 416874

Abstract

The epidemiological features are described of an outbreak of gonorrhoea caused by penicillinase-producing strains of gonococci in 76 patients in Liverpool between February and November 1976. Initially infections were confined to a socially deprived inner city area with a large immigrant population, and subsequent spread of infection remained circumscribed. The characteristics of those patients acquiring these infections were similar to those infected by gonococci of diminished sensitivity to benzylpenicillin, and showed a strong association with adverse social factors. A comparison of the clinical features of patients harbouring sensitive, less sensitive, and penicillinase-producing strains showed severe symptoms and signs in men and a greater involvement of multiple sites in women infected with penicillinase-producing gonococci. Treatment with penicillins failed. Tetracycline was satisfactory in men but was less so in women in whom gonococci persisted in the rectum. Cefuroxime and spectinomycin were effective.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashford W. A., Golash R. G., Hemming V. G. Penicillinase-producing Neisseria gonorrhoeae. Lancet. 1976 Sep 25;2(7987):657–658. doi: 10.1016/s0140-6736(76)92467-3. [DOI] [PubMed] [Google Scholar]
  2. Blog F. B., Chang A., de Koning G. A., Oranje A. P., Stolze E., Bosscher-Koestsier G., de Jonge-Suy M. P., Michel M. F., O'Niel E., de Weerdt-van Ameyden S. Penicillinase-producing strains of Neisseria gonorrhoeae isolated in Rotterdam. Br J Vener Dis. 1977 Apr;53(2):98–100. doi: 10.1136/sti.53.2.98. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Morton R. S. Social indicators and venereal disease. Br J Vener Dis. 1973 Apr;49(2):155–156. doi: 10.1136/sti.49.2.155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Oller L. Z., Wood T. Factors influencing the incidence of gonorrhoea and non-gonococcal urethritis in men in an industrial city. Br J Vener Dis. 1970 Apr;46(2):96–102. doi: 10.1136/sti.46.2.96. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Penicillinase-producing Neisseria gonorrhoeae. Lancet. 1976 Oct 9;2(7989):793–793. [PubMed] [Google Scholar]
  6. Percival A., Rowlands J., Corkill J. E., Alergant C. D., Arya O. P., Rees E., Annels E. H. Penicillinase-producing Gonococci in Liverpool. Lancet. 1976 Dec 25;2(8000):1379–1382. doi: 10.1016/s0140-6736(76)91919-x. [DOI] [PubMed] [Google Scholar]
  7. Phillips I. Beta-lactamase-producing, penicillin-resistant gonococcus. Lancet. 1976 Sep 25;2(7987):656–657. doi: 10.1016/s0140-6736(76)92466-1. [DOI] [PubMed] [Google Scholar]
  8. Piot P. Resistant gonococcus from the ivory coast. Lancet. 1977 Apr 16;1(8016):857–857. doi: 10.1016/s0140-6736(77)92806-9. [DOI] [PubMed] [Google Scholar]
  9. Roberts M., Falkow S. Conjugal transfer of R plasmids in Neisseria gonorrhoeae. Nature. 1977 Apr 14;266(5603):630–631. doi: 10.1038/266630a0. [DOI] [PubMed] [Google Scholar]
  10. Silver P. S., Darling W. M. Penicillin-insensitive gonococci in the Bolton area. Preponderance in young women and immigrants. Br J Vener Dis. 1971 Oct;47(5):367–372. doi: 10.1136/sti.47.5.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Wilkinson A. E., Seth A. D., Rodin P. Infection with penicillinase-producing gonococcus. Br Med J. 1976 Nov 20;2(6046):1233–1233. doi: 10.1136/bmj.2.6046.1233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Willcox R. R. Immigration and venereal disease in Great Britain. Br J Vener Dis. 1966 Dec;42(4):225–237. doi: 10.1136/sti.42.4.225. [DOI] [PMC free article] [PubMed] [Google Scholar]

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