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. 1978 Jun;54(3):165–167. doi: 10.1136/sti.54.3.165

The efficacy of cefuroxime for the treatment of acute gonorrhoea in men.

J D Price, J L Fluker
PMCID: PMC1045482  PMID: 656890

Abstract

This is a report on a clinical trial in which cefuroxime was used for treating 110 men with uncomplicated urethral gonorrhoea. Twenty-three men were given 1 g cefuroxime intramuscularly and 1 g probenecid orally, and 87 were treated with 1.5 g cefuroxime intramuscularly with 1 g probenecid orally. All 18 patients treated with 1 g cefuroxime and 1 g probenecid and seen at least once after treatment, were cured. Sixty-six (98.5%) of 67 patients treated with 1.5 g cefuroxime and 1 g probenecid and seen at least once after treatment, were cured. No side effects were reported. The high cure rates compared favourably with other antibiotics now in regular use and cefuroxime should be of great value especially for patients infected with beta-lactamase producing gonococci.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashford W. A., Golash R. G., Hemming V. G. Penicillinase-producing Neisseria gonorrhoeae. Lancet. 1976 Sep 25;2(7987):657–658. doi: 10.1016/s0140-6736(76)92467-3. [DOI] [PubMed] [Google Scholar]
  2. CURTIS F. R., WILKINSON A. E. A comparison of the in vitro sensitivity of gonococci to penicillin with the results of treatment. Br J Vener Dis. 1958 Jun;34(2):70–82. doi: 10.1136/sti.34.2.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Carroll B. R., Nicol C. S. Trimethoprim-sulphamethoxazole in the treatment of non-gonococcal urethritis and gonorrhoea. Br J Vener Dis. 1970 Feb;46(1):31–33. doi: 10.1136/sti.46.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fluker J. L., Hewitt A. B. Kanamycin in the treatment of rectal gonorrhoea. Br J Vener Dis. 1970 Dec;46(6):454–456. doi: 10.1136/sti.46.6.454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Foord R. D. Cefuroxime: human pharmacokinetics.. Antimicrob Agents Chemother. 1976 May;9(5):741–747. doi: 10.1128/aac.9.5.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gray R. C., Phillips I., Nicol C. S. Treatment of gonorrhoea with three different antibiotic regimes: doxycycline 300 mg., procaine penicillin plus benzyl penicillin 2.4 m.u., benzyl penicillin 5 m.u. plus probenecid. Br J Vener Dis. 1970 Oct;46(5):401–403. doi: 10.1136/sti.46.5.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hooton W. F., Nicol C. S. Kanamycin in the treatment of gonorrhoea in females. Postgrad Med J. 1967 May;(Suppl):68–71. [PubMed] [Google Scholar]
  8. Kvale P. A., Keys T. F., Johnson D. W., Holmes K. K. Single oral dose ampicillin-probenecid treatment of gnorrhea in the male. JAMA. 1971 Mar 1;215(9):1449–1453. [PubMed] [Google Scholar]
  9. O'Callaghan C. H., Sykes R. B., Griffiths A., Thornton J. E. Cefuroxime, a new cephalosporin antibiotic: activity in vitro. Antimicrob Agents Chemother. 1976 Mar;9(3):511–519. doi: 10.1128/aac.9.3.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Olsen G. A., Lomholt G. Gonorrhoea treated by a combination of probenecid and sodium penicillin G. Br J Vener Dis. 1969 Jun;45(2):144–148. doi: 10.1136/sti.45.2.144. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Percival A., Rowlands J., Corkill J. E., Alergant C. D., Arya O. P., Rees E., Annels E. H. Penicillinase-producing Gonococci in Liverpool. Lancet. 1976 Dec 25;2(8000):1379–1382. doi: 10.1016/s0140-6736(76)91919-x. [DOI] [PubMed] [Google Scholar]
  12. Phillips I., King A., Warren C., Watts B. The activity of penicillin and eight cephalosporins on Neisseria gonorrhoeae. J Antimicrob Chemother. 1976 Mar;2(1):31–39. doi: 10.1093/jac/2.1.31. [DOI] [PubMed] [Google Scholar]
  13. Price J. D., Fluker J. L., Giles J. H. Oral talampicillin in the treatment of gonorrhoea. Br J Vener Dis. 1977 Apr;53(2):113–114. doi: 10.1136/sti.53.2.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Reyn A., Schmidt H., Trier M., Bentzon M. W. Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoea. Observation of resistant strains of Neisseria gonorrhoeae. Br J Vener Dis. 1973 Feb;49(1):54–59. doi: 10.1136/sti.49.1.54. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Riddell R. H., Buck A. C. Trimethoprim as an additional selective agent in media for the isolation of N. gonorrhoeae. J Clin Pathol. 1970 Sep;23(6):481–483. doi: 10.1136/jcp.23.6.481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. SIBOULET A., DUREL P. A new "one-minute" treatment of gonorrhoea. Br J Vener Dis. 1961 Dec;37:240–243. doi: 10.1136/sti.37.4.240. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wilkinson A. E., Race J. W., Curtis F. R. Kanamycin in the treatment of gonorrhoea in males. Postgrad Med J. 1967 May;(Suppl):65–67. [PubMed] [Google Scholar]

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