Skip to main content
PMC home page
The British Journal of Venereal Diseases logoLink to The British Journal of Venereal Diseases
. 1978 Dec;54(6):380–385. doi: 10.1136/sti.54.6.380

Treponema pallidum immune adherence test for serodiagnosis of syphilis. 3: Clinical significance and evaluation of treatment.

S Tanaka, T Suzuki, T Numata
PMCID: PMC1045554  PMID: 367525

Abstract

Antibody titres were measured in patients with clinical syphilis, and the effect of treatment on the results of the Treponema pallidum immune adherence (TPIA) test is reported. In the Treponema pallidum haemagglutination (TPHA) test little change in antibody titre occurred after treatment while in the fluorescent treponemal antibody-absorbed (FTA-ABS) test only a slight decrease occurred. The decrease in the antibody titre in the TPIA test was similar to that in the glass plate test, but the findings were different. From the results of gel filtration of sera obtained from patients with syphilis at different intervals after treatment it was apparent that the decrease in antibody titre after treatment mainly concerned the IgM antibody; thus, because of the high sensitivity of the TPIA test to IgM antibody the test is useful in evaluating the effect of treatment.

Full text

PDF
380

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CARPENTER C. M., BOAK R. A., MILLER J. N. Serologic diagnosis of syphilis; the use of Treponema pallidum immobilization and immune adherence tests. Calif Med. 1956 Jul;85(1):30–32. [PMC free article] [PubMed] [Google Scholar]
  2. Garner M. F., Backhouse J. L., Daskalopoulos G., Walsh J. L. The Treponema pallidum haemagglutination (TPHA) test in biological false positive and leprosy sera. J Clin Pathol. 1973 Apr;26(4):258–260. doi: 10.1136/jcp.26.4.258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Garner M. F., Backhouse J. L., Daskalopoulos G., Walsh J. L. Treponema pallidum haemagglutination test for yaws. Comparison with the TPI and FTA-ABS tests. Br J Vener Dis. 1972 Dec;48(6):479–482. doi: 10.1136/sti.48.6.479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HUNTER E. F., DEACON W. E., MEYER P. E. AN IMPROVED FTA TEST FOR SYPHILIS, THE ABSORPTION PROCEDURE (FTA-ABS). Public Health Rep. 1964 May;79:410–412. [PMC free article] [PubMed] [Google Scholar]
  5. Johnston N. A. Neonatal congenital syphilis. Diagnosis by the absorbed fluorescent treponemal antibody (IgM) test. Br J Vener Dis. 1972 Dec;48(6):464–469. doi: 10.1136/sti.48.6.464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kraus S. J., Haserick J. R., Lantz M. A. Atypical FTA-ABS test fluorescence in lupus erythematosus patients. JAMA. 1970 Mar 30;211(13):2140–2141. [PubMed] [Google Scholar]
  7. Kraus S. J., Haserick J. R., Lantz M. A. Fluorescent treponemal antibody-absorption test reactions in lupus erythematosus. N Engl J Med. 1970 Jun 4;282(23):1287–1290. doi: 10.1056/NEJM197006042822303. [DOI] [PubMed] [Google Scholar]
  8. Le Clair R. A. Evaluation of qualitative hemagglutination test for antibodies to Treponema pallidum. J Infect Dis. 1971 Jun;123(6):668–670. doi: 10.1093/infdis/123.6.668. [DOI] [PubMed] [Google Scholar]
  9. Lesiński J., Krach J., Kadziewicz E. Specificity, sensitivity, and diagnostic value of the TPHA test. Br J Vener Dis. 1974 Oct;50(5):334–340. doi: 10.1136/sti.50.5.334. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. O'Neill P., Nicol C. S. IgM class antitreponemal antibody in treated and untreated syphilis. Br J Vener Dis. 1972 Dec;48(6):460–463. doi: 10.1136/sti.48.6.460. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Oxelius V. A., Rorsman H., Laurell A. B. Immunoglobulins of cerebrospinal fluid in syphilis. Br J Vener Dis. 1969 Jun;45(2):121–125. doi: 10.1136/sti.45.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Robertson D. H., McMillan A. Clinical value of the Treponema pallidum haemagglutination test. Br J Vener Dis. 1975 Apr;51(2):79–82. doi: 10.1136/sti.51.2.79. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Tanaka S., Suzuki T., Numata T. Treponema pallidum immune adherence test for serodiagnosis of syphilis. 1: An improved method of the TPIA test. Br J Vener Dis. 1978 Dec;54(6):369–373. doi: 10.1136/sti.54.6.369. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Tanaka S., Suzuki T., Numata T., Tsuyuki K. Treponema pallidum immune adherence test for serodiagnosis of syphilis. 2: Comparison with glass plate, TPHA, and FTA-ABS tests. Br J Vener Dis. 1978 Dec;54(6):374–379. doi: 10.1136/sti.54.6.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wilkinson A. E., Rodin P. IgM-FTA test in syphilis in adults. Its relation to clinical findings. Br J Vener Dis. 1976 Aug;52(4):219–223. doi: 10.1136/sti.52.4.219. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Venereal Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES