Skip to main content
NCBI home page
The British Journal of Venereal Diseases logoLink to The British Journal of Venereal Diseases
. 1978 Dec;54(6):414–421. doi: 10.1136/sti.54.6.414

Management of non-specific urethritis in men. Evaluation of six treatment regimens and effect of other factors including alcohol and sexual intercourse.

O P Arya, C D Alergant, E H Annels, P B Carey, A K Ghosh, A D Goddard
PMCID: PMC1045561  PMID: 737518

Abstract

A trial comparing the efficacy of three different tetracyclines, each in two different dosage regimens, in the treatment of non-specific urethritis is described. There was a significant association between the retreatment rate and sexual intercourse. Age, race, duration of symptoms, previous infection, and indulgence in alcohol did not appear to influence the results whereas treatment of sexual contacts before resumption of sexual intercourse significantly reduced the retreatment rate. Single-dose treatment with doxycycline was shown to be ineffective. Treatment with doxycycline for seven days or triple tetracycline for seven days was less effective than triple tetracycline for 21 days or oxytetracyline for seven or 21 days, all of which gave the same success rate.

Full text

PDF
414

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALERGANT C. D. SINGLE-DOSE TREATMENT OF NON-SPECIFIC URETHRITIS. Br J Vener Dis. 1964 Dec;40:266–267. doi: 10.1136/sti.40.4.266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Arya O. P. Some highlights on the aetiology of the non-gonococcal urethral discharge in males in Kampala, Uganda. East Afr Med J. 1972 Nov;49(11):817–824. [PubMed] [Google Scholar]
  3. Evans B. A. The role of tetracyclines in the treatment of non-specific urethritis. Br J Vener Dis. 1977 Feb;53(1):40–43. doi: 10.1136/sti.53.1.40. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fowler W. Studies in non-gonococcal urethritis therapy. The long-term value of tetracycline. Br J Vener Dis. 1970 Dec;46(6):464–468. doi: 10.1136/sti.46.6.464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Handsfield H. H., Alexander E. R., Pin Wang S., Pedersen A. H., Holmes K. K. Differences in the therapeutic response of chlamydia-positive and chlamydia-negative forms of nongonococcal urethritis. J Am Vener Dis Assoc. 1976 Mar;2(3):5–9. [PubMed] [Google Scholar]
  6. Helmy N., Fowler W. Intensive and prolonged tetracycline therapy in non-specific urethritis. Br J Vener Dis. 1975 Oct;51(5):336–339. doi: 10.1136/sti.51.5.336. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Holmes K. K., Handsfield H. H., Wang S. P., Wentworth B. B., Turck M., Anderson J. B., Alexander E. R. Etiology of nongonococcal urethritis. N Engl J Med. 1975 Jun 5;292(23):1199–1205. doi: 10.1056/NEJM197506052922301. [DOI] [PubMed] [Google Scholar]
  8. John J. Efficacy of prolonged regimes of oxytetracycline in the treatment of nongonococcal urethritis. Br J Vener Dis. 1971 Aug;47(4):266–268. doi: 10.1136/sti.47.4.266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lassus A., Perko R. L., Stubb S., Mattila R., Jansson E. Doxycycline treatment of nongonococcal urethritis with special reference to T-strain mycoplasmas. Br J Vener Dis. 1971 Apr;47(2):126–130. doi: 10.1136/sti.47.2.126. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mahony J. D., Harris J. R., Dougan H. J. Preliminary study of combined sulfametopyrazine and streptomycin single-dosage therapy in nongonococcal urethritis. Br J Clin Pract. 1972 Apr;26(4):173–174. [PubMed] [Google Scholar]
  11. Masterton G., Schofield C. B. Doxycycline HCl (Vibramycin) as a single dose oral treatment of gonococcal and nonspecific urethritis in men. Br J Vener Dis. 1972 Apr;48(2):121–125. doi: 10.1136/sti.48.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Oriel J. D., Reeve P., Wright J. T., Owen J. Chlamydial infection of the male urethra. Br J Vener Dis. 1976 Feb;52(1):46–51. doi: 10.1136/sti.52.1.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Osoba A. O. Epidemiology of urethritis in Ibadan. Br J Vener Dis. 1972 Apr;48(2):116–120. doi: 10.1136/sti.48.2.116. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Willcox R. R. 'Triple tetracycline' in the treatment of non-gonococcal urethritis in males. Br J Vener Dis. 1972 Apr;48(2):137–140. doi: 10.1136/sti.48.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Venereal Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES