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Iron metabolism: transferrin (TF) transports free iron, both the ferrous (Fe2+) and ferric forms (Fe3+), to tissues and organs, such as the bone marrow and liver. Free iron is active after dissociation from TF, while excess intracellular iron is exported from ferroportin (FPN) or stored as Fe3+ in ferritin. Iron is also released by metal divalent conveyor 1 (DMT1).
