Skip to main content
PMC home page
The British Journal of Venereal Diseases logoLink to The British Journal of Venereal Diseases
. 1979 Oct;55(5):351–353. doi: 10.1136/sti.55.5.351

Metronidazole-resistant Trichomonas vaginalis.

A Forsgren, L Forssman
PMCID: PMC1045679  PMID: 315809

Abstract

A 36-year-old woman with symptomatic metronidazole-resistant trichomonal vaginitis for 10 years had a total of 22 courses of treatment with either metronidazole or tinidazole according to different schedules. The minimum trichomonicidal concentration of metronidazole for the strain of Trichomonas vaginalis isolated from the patient was 160 microgram/ml compared with 1.25-10 microgram/ml for other freshly isolated strains. The former strain also showed a definitely decreased sensitivity to ornidazole and tinidazole (80 microgram/ml). The mechanisms behind the appearance of resistance in this clinical isolate are at present unknown and require further study from the theoretical as well as the therapeutic viewpoint.

Full text

PDF
351

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Actor P., Ziv D. S., Pagano J. F. Resistance to metronidazole by Trichomonas foetus in hamsters infected intravaginally. Science. 1969 Apr 25;164(3878):439–440. doi: 10.1126/science.164.3878.439. [DOI] [PubMed] [Google Scholar]
  2. Arnold M. Beobachtungen und Probleme bei der Behandlung der Trichomonas vaginalis. Ther Umsch. 1966 Sep;23(9):356–359. [PubMed] [Google Scholar]
  3. Aure J. C., Gjonnaess H. Metronidazole treatment of trichomonal vaginitis. A comparison of cure rates in 1961 and 1967. Acta Obstet Gynecol Scand. 1969;48(3):440–445. doi: 10.3109/00016346909156659. [DOI] [PubMed] [Google Scholar]
  4. Benazet F., Guillaume L. Induction of in-vivo resistance of trichomonas vaginalis to nitrimidazine. Lancet. 1971 Oct 30;2(7731):982–983. doi: 10.1016/s0140-6736(71)90309-6. [DOI] [PubMed] [Google Scholar]
  5. COSAR C., JULOU L. Activité de l'(hydroxy-2'éthyl)-1 méthyl-2 nitro-5 imidazole (8.823 R. P.) vis-à-vis des infections expérimentales à Trichomonas vaginalis. Ann Inst Pasteur (Paris) 1959 Feb;96(2):238–241. [PubMed] [Google Scholar]
  6. Csonka G. W. Trichomonal vaginitis treated with one dose of metronidazole. Br J Vener Dis. 1971 Dec;47(6):456–458. doi: 10.1136/sti.47.6.456. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DIAMOND L. S. The establishment of various trichomonads of animals and man in axenic cultures. J Parasitol. 1957 Aug;43(4):488–490. [PubMed] [Google Scholar]
  8. De Carneri I., Achilli G., Monti G., Trane F. Induction of in-vivo resistance of trichomonas vaginalis to metronidazole. Lancet. 1969 Dec 13;2(7633):1308–1309. doi: 10.1016/s0140-6736(69)90849-6. [DOI] [PubMed] [Google Scholar]
  9. Forsgren A. Influence of normal human serum on the determination of trichomonicidal drug concentrations. Br J Vener Dis. 1972 Jun;48(3):205–206. doi: 10.1136/sti.48.3.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Forsgren A., Wallin J. Trinidazole--a new preparation for Trichomonas vaginalis infections. I. Laboratory evaluation. Br J Vener Dis. 1974 Apr;50(2):146–147. doi: 10.1136/sti.50.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. KANE P. O., McFADZEAN J. A., SQUIRES S., KING A. J., NICOL C. S. Absorption and excretion of metronidazole. I. Serum concentration and urinary excretion after oral administration. Br J Vener Dis. 1961 Dec;37:273–275. doi: 10.1136/sti.37.4.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Korner B., Jensen H. K. Sensitivity of Trichomonas vaginalis to metronidazole, tinidazole, and nifuratel in vitro. Br J Vener Dis. 1976 Dec;52(6):404–408. doi: 10.1136/sti.52.6.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. McFadzean J. A., Pugh I. M., Squires S. L., Whelan J. P. Further observations on strain sensitivity of Trichomonas vaginalis to metronidazole. Br J Vener Dis. 1969 Jun;45(2):161–162. doi: 10.1136/sti.45.2.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Paredes F. R., Hawkins D. F. Sensitivity of Trichomonas vaginalis to chemotherapeutic agents. J Obstet Gynaecol Br Commonw. 1973 Jan;80(1):86–88. doi: 10.1111/j.1471-0528.1973.tb02138.x. [DOI] [PubMed] [Google Scholar]
  15. Sköld M., Gnarpe H., Hillström L. Ornidazole: a new antiprotozoal compound for treatment of Trichomonas vaginalis infection. Br J Vener Dis. 1977 Feb;53(1):44–48. doi: 10.1136/sti.53.1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Thurner J., Meingassner J. G. Isolation of Trichomonas vaginalis resistant to metronidazole. Lancet. 1978 Sep 30;2(8092 Pt 1):738–738. doi: 10.1016/s0140-6736(78)92739-3. [DOI] [PubMed] [Google Scholar]
  17. Wallin J., Forsgren A. Tinidazole--a new preparation for T. vaginalis infections. II. Clinical evaluation of treatment with a single oral dose. Br J Vener Dis. 1974 Apr;50(2):148–150. doi: 10.1136/sti.50.2.148. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Venereal Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES