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. 1980 Apr;56(2):88–91. doi: 10.1136/sti.56.2.88

Prolonged use of the Greenland method of treatment of gonorrhoea.

A J Evans, G D Morrison, D J Price
PMCID: PMC1045739  PMID: 6770958

Abstract

Of 1081 patients with gonorrhoea treated with probenecid 1 g orally and benzyl penicillin 5 megaunits intramuscularly, 96.7% were cured and no complications were encountered. This treatment regimen was associated with a pronounced reduction in the proportion of gonococcal strains showing diminished sensitivity to penicillin, from 51% to between 4% and 14% over a period of four years. When this treatment method was abandoned, however, the percentage of less sensitive strains rose to 33% over the following 18 months.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CRADOCK-WATSON J. E., SHOOTER R. A., NICOL C. S. Sensitivity of strains of gonococci to penicillin, sulphathiazole, and streptomycin. Br Med J. 1958 May 10;1(5079):1091–1092. doi: 10.1136/bmj.1.5079.1091. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CURTIS F. R., WILKINSON A. E. A comparison of the in vitro sensitivity of gonococci to penicillin with the results of treatment. Br J Vener Dis. 1958 Jun;34(2):70–82. doi: 10.1136/sti.34.2.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DALLAS N. L. Penicillin treatment failures in male gonorrhoea. Br J Vener Dis. 1958 Sep;34(3):194–195. doi: 10.1136/sti.34.3.194. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Evans A. J., Churcher G. M., Human R. P. Sulphamethoxazole-trimethoprim in the treatment of gonorrhoea. Br J Vener Dis. 1972 Jun;48(3):179–181. doi: 10.1136/sti.48.3.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Evans A. J. Relapse of gonorrhoea after treatment with penicillin or streptomycin. Br J Vener Dis. 1966 Dec;42(4):251–262. doi: 10.1136/sti.42.4.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gjessing H. C., Odegaard K. Intramuscular injection of procaine penicillin combined with oral administration of chloramphenicol in the treatment of gonorrhoea. Br J Vener Dis. 1966 Jun;42(2):107–109. doi: 10.1136/sti.42.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gray R. C., Phillips I., Nicol C. S. Treatment of gonorrhoea with three different antibiotic regimes: doxycycline 300 mg., procaine penicillin plus benzyl penicillin 2.4 m.u., benzyl penicillin 5 m.u. plus probenecid. Br J Vener Dis. 1970 Oct;46(5):401–403. doi: 10.1136/sti.46.5.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jaffe H. W., Biddle J. W., Thornsberry C., Johnson R. E., Kaufman R. E., Reynolds G. H., Wiesner P. J. National gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results. N Engl J Med. 1976 Jan 1;294(1):5–9. doi: 10.1056/NEJM197601012940102. [DOI] [PubMed] [Google Scholar]
  9. Olsen G. A., Lomholt G. Gonorrhoea treated by a combination of probenecid and sodium penicillin G. Br J Vener Dis. 1969 Jun;45(2):144–148. doi: 10.1136/sti.45.2.144. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Wigfield A. S., Selkon J. B., Rich G. E. Single-session treatment of uncomplicated gonorrhoea in men, using penicillin combined with cotrimoxazole. Controlled trial comparing four different treatment schedules with observations on antibiotic sensitivities of gonococci and a review of the literature. Br J Vener Dis. 1973 Jun;49(3):277–290. doi: 10.1136/sti.49.3.277. [DOI] [PMC free article] [PubMed] [Google Scholar]

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