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The British Journal of Venereal Diseases logoLink to The British Journal of Venereal Diseases
. 1980 Jun;56(3):163–168. doi: 10.1136/sti.56.3.163

Epidemiology of infection by serotypes D to K of chlamydia trachomatis.

E M Dunlop, S Darougar, J D Treharne
PMCID: PMC1045760  PMID: 7427689

Abstract

Non-specific urethritis (NSU) is a sexually transmitted disease; 50% of cases are due to Chlamydia trachomatis, so that this is the commonest sexually transmitted infection in the developed world. Chlamydial infection is now readily diagnosable and the evidence increasingly suggests that it is underdiagnosed. Chlamydial conjunctivitis (in the newborn baby or the adult) in the developed world is a complication of sexually transmitted genital infection by C trachomatis and it indicates a large reservoir of such infections. Because of the association of sexually transmitted diseases, systemic treatment for such chlamydial conjunctivitis should not be given until full genital and serological investigators have been carried out. Chlamydial infection causes serious complications (that were formerly often thought to be gonococcal), such as epididymitis in young men and salpingitis on young women. It may cause local complications in the eye of the newborn baby and even pneumonia in babies and fatal endocarditis in adults. The diagnosis of NSU should lead to the correct treatment of the male patient and of his sexual partners. It is the promiscuous woman, who does not have a regular sexual partner to report back to her that he has NSU, who is at particular risk of undiagnosed chlamydial infection. Routine genital investigations for chlamydia are particularly indicated in her case. Following the parallel of gonorrhoea, it seems that the use of contact tracers may be an effective method for controlling chlamydial infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beem M. O., Saxon E. M. Respiratory-tract colonization and a distinctive pneumonia syndrome in infants infected with Chlamydia trachomatis. N Engl J Med. 1977 Feb 10;296(6):306–310. doi: 10.1056/NEJM197702102960604. [DOI] [PubMed] [Google Scholar]
  2. Berger R. E., Alexander E. R., Monda G. D., Ansell J., McCormick G., Holmes K. K. Chlamydia trachomatis as a cause of acute "idiopathic" epididymitis. N Engl J Med. 1978 Feb 9;298(6):301–304. doi: 10.1056/NEJM197802092980603. [DOI] [PubMed] [Google Scholar]
  3. Bowie W. R., Alexander E. R., Holmes K. K. Chlamydial pharyngitis? Sex Transm Dis. 1977 Oct-Dec;4(4):140–141. doi: 10.1097/00007435-197710000-00004. [DOI] [PubMed] [Google Scholar]
  4. Burns D. C., Darougar S., Thin R. N., Lothian L., Nicol C. S. Isolation of Chlamydia from women attending a clinic for sexually transmitted disease. Br J Vener Dis. 1975 Oct;51(5):314–318. doi: 10.1136/sti.51.5.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chandler J. W., Alexander E. R., Pheiffer T. A., Wang S. P., Holmes K. K., English M. Ophthalmia neonatorum associated with maternal chlamydial infections. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1977 Mar-Apr;83(2):302–308. [PubMed] [Google Scholar]
  6. Davies J. A., Rees E., Hobson D., Karayiannis P. Isolation of Chlamydia trachomatis from Bartholin's ducts. Br J Vener Dis. 1978 Dec;54(6):409–413. doi: 10.1136/sti.54.6.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Digiacomo R. F., Gale J. L., Wang S. P., Kiviat M. D. Chlamydial infection of the male baboon urethra. Br J Vener Dis. 1975 Oct;51(5):310–313. doi: 10.1136/sti.51.5.310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Dunlop E. M., Freedman A., Garland J. A., Harper I. A., Jones B. R., Race J. W., Du Toit M. S., Treharne J. D. Infection by Bedsoniae and the possibility of spurious isolation. 2. Genital infection, disease of the eye, Reiter's disease. Am J Ophthalmol. 1967 May;63(5 Suppl):1073–1081. doi: 10.1016/0002-9394(67)94085-8. [DOI] [PubMed] [Google Scholar]
  9. Dunlop E. M., Jones B. R., Darougar S., Treharne J. D. Chlamydia and non-specific urethritis. Br Med J. 1972 Jun 3;2(5813):575–577. doi: 10.1136/bmj.2.5813.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Dunlop E. M., Lamb A. M., King D. M. Improved tracing of contacts of heterosexual men with gonorrhoea. Relationship of altered female to male ratios. Br J Vener Dis. 1971 Jun;47(3):192–195. doi: 10.1136/sti.47.3.192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Goldmeier D., Darougar S. Isolation of Chlamydia trachomatis from throat and rectum of homosexual men. Br J Vener Dis. 1977 Jun;53(3):184–185. doi: 10.1136/sti.53.3.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gordon F. B., Harper I. A., Quan A. L., Treharne J. D., Dwyer R. S., Garland J. A. Detection of Chlamydia (Bedsonia) in certain infections of man. I. Laboratory procedures: comparison of yolk sac and cell culture for detection and isolation. J Infect Dis. 1969 Oct;120(4):451–462. doi: 10.1093/infdis/120.4.451. [DOI] [PubMed] [Google Scholar]
  13. Hamark B., Brorsson J. E., Eilard T., Forssman L. Salpingitis and Chlamydiae subgroup A. Acta Obstet Gynecol Scand. 1976;55(4):377–378. doi: 10.3109/00016347609158517. [DOI] [PubMed] [Google Scholar]
  14. Hammerschlag M. R. Chlamydial pneumonia in infants. N Engl J Med. 1978 May 11;298(19):1083–1084. doi: 10.1056/NEJM197805112981912. [DOI] [PubMed] [Google Scholar]
  15. Hilton A. L., Richmond S. J., Milne J. D., Hindley F., Clarke S. K. Chlamydia A in the female genital tract. Br J Vener Dis. 1974 Feb;50(1):1–10. doi: 10.1136/sti.50.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Hobson D., Johnson F. W., Rees E., Tait I. A. Simplified method for diagnosis of genital and ocular infections with Chlamydia. Lancet. 1974 Sep 7;2(7880):555–556. doi: 10.1016/s0140-6736(74)91879-0. [DOI] [PubMed] [Google Scholar]
  17. Holmes K. K., Handsfield H. H., Wang S. P., Wentworth B. B., Turck M., Anderson J. B., Alexander E. R. Etiology of nongonococcal urethritis. N Engl J Med. 1975 Jun 5;292(23):1199–1205. doi: 10.1056/NEJM197506052922301. [DOI] [PubMed] [Google Scholar]
  18. Jones B. R. The prevention of blindness from trachoma. Trans Ophthalmol Soc U K. 1975 Apr;95(1):16–33. [PubMed] [Google Scholar]
  19. Mordhorst C. H., Dawson C. Sequelae of neonatal inclusion conjunctivitis and associated disease in parents. Am J Ophthalmol. 1971 Apr;71(4):861–867. doi: 10.1016/0002-9394(71)90256-x. [DOI] [PubMed] [Google Scholar]
  20. Mordhorst C. H., Wang S. P., Grayston J. T. Childhood trachoma in a nonendemic area. Danish trachoma patients and their close contacts, 1963 to 1973. JAMA. 1978 Apr 28;239(17):1765–1771. doi: 10.1001/jama.239.17.1765. [DOI] [PubMed] [Google Scholar]
  21. Mårdh P. A., Ripa T., Svensson L., Weström L. Chilamydia trachomatis infection in patients with acute salpingitis. N Engl J Med. 1977 Jun 16;296(24):1377–1379. doi: 10.1056/NEJM197706162962403. [DOI] [PubMed] [Google Scholar]
  22. Nayyar K. C., O'Neill J. J., Hambling M. H., Waugh M. A. Isolation of Chlamydia trachomatis from women attending a clinic for sexually transmitted diseases. Br J Vener Dis. 1976 Dec;52(6):396–398. doi: 10.1136/sti.52.6.396. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Oriel J. D., Powis P. A., Reeve P., Miller A., Nicol C. S. Chlamydial infections of the cervix. Br J Vener Dis. 1974 Feb;50(1):11–16. doi: 10.1136/sti.50.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Oriel J. D., Reeve P., Powis P., Miller A., Nicol C. S. Chlamydial infection. Isolation of Chlamydia from patients with non-specific genital infection. Br J Vener Dis. 1972 Dec;48(6):429–436. doi: 10.1136/sti.48.6.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Oriel J. D., Reeve P., Wright J. T., Owen J. Chlamydial infection of the male urethra. Br J Vener Dis. 1976 Feb;52(1):46–51. doi: 10.1136/sti.52.1.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Perroud H. M., Miedzybrodzka K. Chlamydial infection of the urethra in men. Br J Vener Dis. 1978 Feb;54(1):45–49. doi: 10.1136/sti.54.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Rees E., Tait I. A., Hobson D., Byng R. E., Johnson F. W. Neonatal conjunctivitis caused by Neisseria gonorrhoeae and Chlamydia trachomatis. Br J Vener Dis. 1977 Jun;53(3):173–179. doi: 10.1136/sti.53.3.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Ridgway G. L., Oriel J. D. Interrelationship of Chlamydia trachomatis and other pathogens in the female genital tract. J Clin Pathol. 1977 Oct;30(10):933–936. doi: 10.1136/jcp.30.10.933. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Rodin P. Asymptomatic non-specific urethritis. Br J Vener Dis. 1971 Dec;47(6):452–453. doi: 10.1136/sti.47.6.452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Schachter J., Atwood G. Chlamydial pharyngitis? J Am Vener Dis Assoc. 1975 Sep;2(1):12–12. [PubMed] [Google Scholar]
  31. Schachter J., Dawson C. R. Is trachoma an ocular component of a more generalised chlamydial infection? Lancet. 1979 Mar 31;1(8118):702–703. doi: 10.1016/s0140-6736(79)91151-6. [DOI] [PubMed] [Google Scholar]
  32. Schachter J., Dawson C. R. Is trachoma an ocular component of a more generalised chlamydial infection? Lancet. 1979 Mar 31;1(8118):702–703. doi: 10.1016/s0140-6736(79)91151-6. [DOI] [PubMed] [Google Scholar]
  33. Schachter J., Hanna L., Hill E. C., Massad S., Sheppard C. W., Conte J. E., Jr, Cohen S. N., Meyer K. F. Are chlamydial infections the most prevalent venereal disease? JAMA. 1975 Mar 24;231(12):1252–1255. [PubMed] [Google Scholar]
  34. Simmons P. D. Evaluation of the early morning smear investigation. Br J Vener Dis. 1978 Apr;54(2):128–129. doi: 10.1136/sti.54.2.128. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. TANG F. F., CHANG H. L., HUANG Y. T., WANG K. C. Studies on the etiology of trachoma with special reference to isolation of the virus in chick embryo. Chin Med J. 1957 Jun;75(6):429–447. [PubMed] [Google Scholar]
  36. Terho P. Chlamydia trachomatis in non-specific urethritis. Br J Vener Dis. 1978 Aug;54(4):251–256. doi: 10.1136/sti.54.4.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Vaughan-Jackson J. D., Dunlop E. M., Darougar S., Dwyer R. S., Jones B. R. Chlamydial infection. Results of tests for Chlamydia in patients suffering from acute Reiter's disease compared with results of tests of the genital tract and rectum in patients with ocular infection due to TRIC agent. Br J Vener Dis. 1972 Dec;48(6):445–451. doi: 10.1136/sti.48.6.445. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Woolfitt J. M., Watt L. Chlamydial infection of the urogenital tract in promiscuous and non-promiscuous women. Br J Vener Dis. 1977 Apr;53(2):93–95. doi: 10.1136/sti.53.2.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. van der Bel-Kahn J. M., Watanakunakorn C., Menefee M. G., Long H. D., Dicter R. Chlamydia trachomatis endocarditis. Am Heart J. 1978 May;95(5):627–636. doi: 10.1016/0002-8703(78)90305-8. [DOI] [PubMed] [Google Scholar]

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