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. 2023 Aug 18;15(8):2157. doi: 10.3390/pharmaceutics15082157

Figure 3.

Figure 3

Characterization of LA67-RL-Gel. (A) The influence of independent variables on response variables. (a) contour plots, (b) 3-D response plots, and (c) 3-D response plot of the predicted theoretical values. (B) The phase transition photograph of the thermo-sensitive hydrogel. (C) Injectability of LA67-RL-Gel. The yellow circle showes the in vivo state of the hydrogel. (D) Hydrogel injected subcutaneously into nude mice. (E) SEM images of LA67-RL-Gel (scale bar: 10 μm). The dashed box indicates a localized enlargement of the hydrogel. (F) Rheological properties. (G) The pH of LA67-RL-Gel was at 0 and 7 days of storage (n = 3, means ± SD). (H) LA67-RL-Gel was degraded at 0 and 7 days of storage (n = 3, means ± SD). (I) The size stability and PDI stability of LA67-RL and LA67-RL-Gel for 7 days (n = 3, means ± SD). (J) The drug release behavior of LA67-RL and LA67-RL-Gel within 72 h (n = 6, means ± SD).