Skip to main content
The British Journal of Venereal Diseases logoLink to The British Journal of Venereal Diseases
. 1980 Aug;56(4):223–226. doi: 10.1136/sti.56.4.223

Detection of antigonococcal IgA in cervical secretions by indirect immunofluorescence: an evaluation as a diagnostic test.

A McMillan, G McNeillage, H Young, S S Bain
PMCID: PMC1045782  PMID: 6775763

Abstract

Using an indirect immunofluorescent-antibody method, antigonococcal IgA was detected in the cervical secretions of 56 (72%) of 78 women with untreated gonorrhoea but in only 25 (5%) of 490 non-infected women. The low sensitivity--comparable to that of Gram-stain microscopy--the expense, and the laboriousness of the test militate against its use as a routine diagnostic procedure.

Full text

PDF
223

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barlow D., Phillips I. Gonorrhoea in women. Diagnostic, clinical, and laboratory aspects. Lancet. 1978 Apr 8;1(8067):761–764. doi: 10.1016/s0140-6736(78)90870-x. [DOI] [PubMed] [Google Scholar]
  2. Chipperfield E. J., Evans B. A. Effect of local infection and oral contraception on immunoglobulin levels in cervical mucus. Infect Immun. 1975 Feb;11(2):215–221. doi: 10.1128/iai.11.2.215-221.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ison C. A., Glynn A. A. Classes of antibodies in acute gonorrhoea. Lancet. 1979 Jun 2;1(8127):1165–1168. doi: 10.1016/s0140-6736(79)91845-2. [DOI] [PubMed] [Google Scholar]
  4. Kearns D. H., O'Reilly R. J., Lee L., Welch B. G. Secretory IgA antibodies in the urethral exudate of men with uncomplicated urethritis due to Neisseria gonorrhoeae. J Infect Dis. 1973 Jan;127(1):99–101. doi: 10.1093/infdis/127.1.99. [DOI] [PubMed] [Google Scholar]
  5. Koransky J. R., Jacobs N. F., Jr Serologic testing for gonorrhea. Sex Transm Dis. 1977 Jan-Mar;4(1):27–31. doi: 10.1097/00007435-197701000-00009. [DOI] [PubMed] [Google Scholar]
  6. Lind I. Identification of Neisseria gonorrhoeae by means of fluorescent antibody technique. Acta Pathol Microbiol Scand. 1967;70(4):613–629. doi: 10.1111/j.1699-0463.1967.tb01330.x. [DOI] [PubMed] [Google Scholar]
  7. McMillan A., McNeillage G., Young H., Bain S. R. Serum immunoglobulin response in uncomplicated gonorrhoea. Br J Vener Dis. 1979 Feb;55(1):5–9. doi: 10.1136/sti.55.1.5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McMillan A., McNeillage G., Young H., Bain S. S. Secretory antibody response of the cervix to infection with Neisseria gonorrhoeae. Br J Vener Dis. 1979 Aug;55(4):265–270. doi: 10.1136/sti.55.4.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. O'Reilly R. J., Lee L., Welch B. G. Secretory IgA antibody responses to Neisseria gonorrhoeae in the genital secretions of infected females. J Infect Dis. 1976 Feb;133(2):113–125. doi: 10.1093/infdis/133.2.113. [DOI] [PubMed] [Google Scholar]
  10. O'Reilly R. J., Welch B. G., Kellogg D. S., Jr An indirect fluorescent-antibody technique for study of uncomplicated gonorrhea. II. Selection and characterization of the strain of Neisseria gonorrhoeae used as antigen. J Infect Dis. 1973 Jan;127(1):77–83. doi: 10.1093/infdis/127.1.77. [DOI] [PubMed] [Google Scholar]
  11. Samson R. R., McClelland D. B., Shearman D. J. Studies on the quantitation of immunoglobulin in human intestinal secretions. Gut. 1973 Aug;14(8):616–626. doi: 10.1136/gut.14.8.616. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wilkinson A. E. Indirect fluorescence test for the detection of anti-gonoccocal antibodies. Br J Vener Dis. 1975 Feb;51(1):28–30. doi: 10.1136/sti.51.1.28. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Venereal Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES