Abstract
Using an indirect immunofluorescent-antibody method, antigonococcal IgA was detected in the cervical secretions of 56 (72%) of 78 women with untreated gonorrhoea but in only 25 (5%) of 490 non-infected women. The low sensitivity--comparable to that of Gram-stain microscopy--the expense, and the laboriousness of the test militate against its use as a routine diagnostic procedure.
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Selected References
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- Barlow D., Phillips I. Gonorrhoea in women. Diagnostic, clinical, and laboratory aspects. Lancet. 1978 Apr 8;1(8067):761–764. doi: 10.1016/s0140-6736(78)90870-x. [DOI] [PubMed] [Google Scholar]
- Chipperfield E. J., Evans B. A. Effect of local infection and oral contraception on immunoglobulin levels in cervical mucus. Infect Immun. 1975 Feb;11(2):215–221. doi: 10.1128/iai.11.2.215-221.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ison C. A., Glynn A. A. Classes of antibodies in acute gonorrhoea. Lancet. 1979 Jun 2;1(8127):1165–1168. doi: 10.1016/s0140-6736(79)91845-2. [DOI] [PubMed] [Google Scholar]
- Kearns D. H., O'Reilly R. J., Lee L., Welch B. G. Secretory IgA antibodies in the urethral exudate of men with uncomplicated urethritis due to Neisseria gonorrhoeae. J Infect Dis. 1973 Jan;127(1):99–101. doi: 10.1093/infdis/127.1.99. [DOI] [PubMed] [Google Scholar]
- Koransky J. R., Jacobs N. F., Jr Serologic testing for gonorrhea. Sex Transm Dis. 1977 Jan-Mar;4(1):27–31. doi: 10.1097/00007435-197701000-00009. [DOI] [PubMed] [Google Scholar]
- Lind I. Identification of Neisseria gonorrhoeae by means of fluorescent antibody technique. Acta Pathol Microbiol Scand. 1967;70(4):613–629. doi: 10.1111/j.1699-0463.1967.tb01330.x. [DOI] [PubMed] [Google Scholar]
- McMillan A., McNeillage G., Young H., Bain S. R. Serum immunoglobulin response in uncomplicated gonorrhoea. Br J Vener Dis. 1979 Feb;55(1):5–9. doi: 10.1136/sti.55.1.5. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McMillan A., McNeillage G., Young H., Bain S. S. Secretory antibody response of the cervix to infection with Neisseria gonorrhoeae. Br J Vener Dis. 1979 Aug;55(4):265–270. doi: 10.1136/sti.55.4.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Reilly R. J., Lee L., Welch B. G. Secretory IgA antibody responses to Neisseria gonorrhoeae in the genital secretions of infected females. J Infect Dis. 1976 Feb;133(2):113–125. doi: 10.1093/infdis/133.2.113. [DOI] [PubMed] [Google Scholar]
- O'Reilly R. J., Welch B. G., Kellogg D. S., Jr An indirect fluorescent-antibody technique for study of uncomplicated gonorrhea. II. Selection and characterization of the strain of Neisseria gonorrhoeae used as antigen. J Infect Dis. 1973 Jan;127(1):77–83. doi: 10.1093/infdis/127.1.77. [DOI] [PubMed] [Google Scholar]
- Samson R. R., McClelland D. B., Shearman D. J. Studies on the quantitation of immunoglobulin in human intestinal secretions. Gut. 1973 Aug;14(8):616–626. doi: 10.1136/gut.14.8.616. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilkinson A. E. Indirect fluorescence test for the detection of anti-gonoccocal antibodies. Br J Vener Dis. 1975 Feb;51(1):28–30. doi: 10.1136/sti.51.1.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
