Table 1.

Summary of the potential effects of minor cannabinoids in various dermatological diseases.

Dermatological Diseases	Cannabinoid	Potential Mechanism of Action	Literature
Psoriasis	CBN CBC Ajulemic acid	Inhibition of excessive keratinocyte divisions; inhibition of the proliferation of keratinocytes; inhibition of the signaling of the Wnt/β-catenin pathway; inhibition of the activity of pro-inflammatory cytokines and other inflammatory mediators; increasing the synthesis of 15d-PGJ2—prostaglandins; the mechanism of action is the suppression of cyclooxygenase-2 (COX-2)	[13,40,41]
Acne	CBDV CBC THCV WIN-55,212-2 Ajulemic acid	Reduction in the production of sebum; inhibition of the growth of bacteria C. acnes; regulation of the secretion of sebum; anti-inflammatory and antibacterial properties	[47,48,49,50,51]
Atopic Dermatitis (AD)	CBG CBDV	The ability to inhibit the action of enzymes responsible for the synthesis of fatty acids, such as arachidonic acid, antibacterial and antifungal activity; the ability to inhibit the activity of pro-inflammatory cytokines such as interleukin 6 and 17A	[57,58,59,60,61,62]
Allergic Contact Dermatitis (ACZ)	CBD THC	Relieving the symptoms of ACZ by reducing inflammation and itching of the skin	[64,65,66]
Anti-inflamatory (requires further detailed research)	CBM CBE	Inhibition of pro-inflammatory biomarkers	[67,68]