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. 1981 Aug;57(4):256–258. doi: 10.1136/sti.57.4.256

Penicillinase-producing Neisseria gonorrhoeae in Riyadh, Saudi Arabia.

M N Chowdhury, S S Pareek, E S Mahgoub
PMCID: PMC1045936  PMID: 6791760

Abstract

Of 83 strains of Neisseria gonorrhoeae isolated in Riyadh, Saudi Arabia, between April 1979 and August 1980, 10 produced beta-lactamase and had minimum inhibitory concentrations (MICs) of penicillin between 1 and greater than or equal to 4 micrograms/ml. Of the 73 (88%) non-penicillinase-producing strains, 55% had diminished sensitivity to penicillin (MIC = 0.06 micrograms/ml) and 11 (15%) were highly resistant (MICs ranging from 0.5-2 micrograms/ml). This high incidence of resistance may be due to widespread abuse of antibiotics; it also confirms that two mechanisms of resistance to penicillin exist in this species.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amies C. R. Sensitivity of Neisseria gonorrhoeae to penicillin and other antibiotics. Studies carried out in Toronto during the period 1961 to 1968. Br J Vener Dis. 1969 Sep;45(3):216–222. doi: 10.1136/sti.45.3.216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Arya O. P., Rees E., Percival A., Alergant C. D., Annels E. H., Turner G. C. Epidemiology and treatment of gonorrhoea caused by penicillinase-producing strains in Liverpool. Br J Vener Dis. 1978 Feb;54(1):28–35. doi: 10.1136/sti.54.1.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ashford W. A., Golash R. G., Hemming V. G. Penicillinase-producing Neisseria gonorrhoeae. Lancet. 1976 Sep 25;2(7987):657–658. doi: 10.1016/s0140-6736(76)92467-3. [DOI] [PubMed] [Google Scholar]
  4. Bell S. M., Plowman D. Mechanisms of ampicillin resistance in Haemophilus influenzae from respiratory tract. Lancet. 1980 Feb 9;1(8163):279–280. doi: 10.1016/s0140-6736(80)90778-3. [DOI] [PubMed] [Google Scholar]
  5. Berg S. W., Kilpatrick M. E., Harrison W. O., McCutchan J. A. Cefoxitin as a single-dose treatment for urethritis caused by penicillinase-producing Neisseria gonorrhoeae. N Engl J Med. 1979 Sep 6;301(10):509–511. doi: 10.1056/NEJM197909063011001. [DOI] [PubMed] [Google Scholar]
  6. Bijkerk H. Penicillinase-producing gonococci in the Netherlands. Br J Vener Dis. 1980 Aug;56(4):243–243. doi: 10.1136/sti.56.4.243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Grunder K., Petzoldt D. Sensitivity of Neisseria gonorrhoeae to spectinomycin and thiamphenicol. Br J Vener Dis. 1980 Aug;56(4):252–254. doi: 10.1136/sti.56.4.252. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hallett A. F., Appelbaum P. C., Cooper R., Mokgokong S., Monale D. Penicillinase-producing Neisseria gonorrhoeae from South Africa. Lancet. 1977 Jun 4;1(8023):1205–1205. doi: 10.1016/s0140-6736(77)92741-6. [DOI] [PubMed] [Google Scholar]
  9. Jaffe H. W., Biddle J. W., Thornsberry C., Johnson R. E., Kaufman R. E., Reynolds G. H., Wiesner P. J. National gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results. N Engl J Med. 1976 Jan 1;294(1):5–9. doi: 10.1056/NEJM197601012940102. [DOI] [PubMed] [Google Scholar]
  10. Moses J. M., Desai M. S., Bhosle C. B., Trasi M. S. Present pattern of antibiotic sensitivity of gonococcal strains isolated in Bombay. Br J Vener Dis. 1971 Aug;47(4):273–278. doi: 10.1136/sti.47.4.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Nayyar K. C., Michel M. F., Stolz E. Antibiotic sensitivities of gonococci isolated in Rotterdam and results of treatment with cefuroxime. Br J Vener Dis. 1980 Aug;56(4):249–251. doi: 10.1136/sti.56.4.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Olsen G. A., Lomholt G. Gonorrhoea treated by a combination of probenecid and sodium penicillin G. Br J Vener Dis. 1969 Jun;45(2):144–148. doi: 10.1136/sti.45.2.144. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Osoba A. O., Montefiore D. G., Sogbetun A. O., Alausa K. O., Anong C. N. Sensitivity pattern of Neisseria gonorrhoeae to penicillin and screening for beta-lactamase production in Ibadan, Nigeria. Br J Vener Dis. 1977 Oct;53(5):304–307. doi: 10.1136/sti.53.5.304. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Percival A., Rowlands J., Corkill J. E., Alergant C. D., Arya O. P., Rees E., Annels E. H. Penicillinase-producing Gonococci in Liverpool. Lancet. 1976 Dec 25;2(8000):1379–1382. doi: 10.1016/s0140-6736(76)91919-x. [DOI] [PubMed] [Google Scholar]
  15. Phillips I. Beta-lactamase-producing, penicillin-resistant gonococcus. Lancet. 1976 Sep 25;2(7987):656–657. doi: 10.1016/s0140-6736(76)92466-1. [DOI] [PubMed] [Google Scholar]
  16. Plorde J. J., Kidan T. G., Wright L. J. Penicillin sensitivity of gonococci in Ethiopia. Br J Vener Dis. 1973 Jun;49(3):260–262. doi: 10.1136/sti.49.3.260. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. REYN A., KORNER B., BENTZON M. W. Effects of penicillin, streptomycin, and tetracycline on N. gonorrhoeae isolated in 1944 and in 1957. Br J Vener Dis. 1958 Dec;34(4):227–239. doi: 10.1136/sti.34.4.227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rajan V. S., Sng E. H., Pang R., Tan N. J., Thirumoorthy T., Yeo K. L. HR 756--a new cephalosporin in the treatment of gonorrhoea caused by ordinary and penicillinase-producing strains of Neisseria gonorrhoeae. Br J Vener Dis. 1980 Aug;56(4):255–258. doi: 10.1136/sti.56.4.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rodin P., Seth A. D., King D. M., Wilkinson A. E. Sensitivity to penicillin of gonococci in different racial groups. Br J Vener Dis. 1980 Oct;56(5):308–310. doi: 10.1136/sti.56.5.308. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Siegel M. S., Thornsberry C., Biddle J. W., O'Mara P. R., Perine P. L., Wiesner P. J. Penicillinase-producing Neisseria gonorrhoeae: results of surveillance in the United States. J Infect Dis. 1978 Feb;137(2):170–175. doi: 10.1093/infdis/137.2.170. [DOI] [PubMed] [Google Scholar]
  21. Sng E. H., Yeo K. L., Rajan V. S., Lim A. L. Comparison of methods for the detection of penicillinase-producing Neisseria gonorrhoeae. Br J Vener Dis. 1980 Oct;56(5):311–313. doi: 10.1136/sti.56.5.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Wang F. H. Beta-lactamase-producing gonococci in Hong Kong. Br J Vener Dis. 1980 Aug;56(4):270–270. doi: 10.1136/sti.56.4.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Wheldon D. B., Slack M. P. An evaluation of Intralactam, a preparation for the detection of beta-lactamase production by Haemophilus influenzae. J Clin Pathol. 1979 Jul;32(7):738–740. doi: 10.1136/jcp.32.7.738. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Willcox R. R. A survey of problems in the antibiotic treatment of gonorrhoea. With special reference to South-East Asia. Br J Vener Dis. 1970 Jun;46(3):217–242. doi: 10.1136/sti.46.3.217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Willcox R. R. A world-wide view of venereal disease. Br J Vener Dis. 1972 Jun;48(3):163–176. doi: 10.1136/sti.48.3.163. [DOI] [PMC free article] [PubMed] [Google Scholar]

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