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. 1982 Feb;58(1):44–47. doi: 10.1136/sti.58.1.44

Incidence of herpes simplex virus types 1 and 2 isolated in patients with herpes genitalis in Sheffield.

I G Barton, G R Kinghorn, S Najem, L S Al-Omar, C W Potter
PMCID: PMC1045999  PMID: 6275940

Abstract

Thirty-one strains of herpesvirus (HSV), isolated from patients presenting with the clinical features of herpes genitalis, were typed by polypeptide analysis of virus proteins in sodium dodecyl sulphate polyacrylamide gels. Nineteen (61.3%) of the isolates were shown to be HSV type 1 and 12 (38.7%) HSV type 2. There was no obvious difference in the incidence of HSV-1 in primary or recurrent infections and no apparent correlation between the genital site of isolation and virus type. The high incidence of genital HSV-1 infection in this group of patients is probably due to the increased practice of oro-genital contact and has possible implications for the future development of drugs and vaccines in the control of genital herpes.

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Selected References

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  1. Cassai E. N., Sarmiento M., Spear P. G. Comparison of the virion proteins specified by herpes simplex virus types 1 and 2. J Virol. 1975 Nov;16(5):1327–1331. doi: 10.1128/jvi.16.5.1327-1331.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cortini R., Wilkie N. M. Physical maps for HSV type 2 DNA with five restriction endonucleases. J Gen Virol. 1978 May;39(2):259–280. doi: 10.1099/0022-1317-39-2-259. [DOI] [PubMed] [Google Scholar]
  3. De Clercq E., Descamps J., De Somer P., Barr P. J., Jones A. S., Walker R. T. (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent. Proc Natl Acad Sci U S A. 1979 Jun;76(6):2947–2951. doi: 10.1073/pnas.76.6.2947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dowdle W. R., Nahmias A. J., Harwell R. W., Pauls F. P. Association of antigenic type of Herpesvirus hominis with site of viral recovery. J Immunol. 1967 Nov;99(5):974–980. [PubMed] [Google Scholar]
  5. Kaufman R. H., Gardner H. L., Rawls W. E., Dixon R. E., Young R. L. Clinical features of herpes genitalis. Cancer Res. 1973 Jun;33(6):1446–1451. [PubMed] [Google Scholar]
  6. Lonsdale D. M. A rapid technique for distinguishing herpes-simplex virus type 1 from type 2 by restriction-enzyme technology. Lancet. 1979 Apr 21;1(8121):849–852. doi: 10.1016/s0140-6736(79)91265-0. [DOI] [PubMed] [Google Scholar]
  7. Nahmias A. J., Chiang W. T., Del Buono I., Duffey A. Typing of Herpesvirus hominis strains by a direct immunofluorescent technique. Proc Soc Exp Biol Med. 1969 Oct;132(1):386–390. doi: 10.3181/00379727-132-34221. [DOI] [PubMed] [Google Scholar]
  8. Nahmias A. J., Dowdle W. R. Antigenic and biologic differences in herpesvirus hominis. Prog Med Virol. 1968;10:110–159. [PubMed] [Google Scholar]
  9. Park N. H., Pavan-Langston D., Hettinger M. E., McLean S. L., Albert D. M., Lin T. S., Prusoff W. H. Topical therapeutic efficacy of 9-(2-hydroxyethoxymethyl)guanine and 5-iodo-5'-amino-2',5'-dideoxyuridine on oral infection with herpes simplex virus in mice. J Infect Dis. 1980 May;141(5):575–579. doi: 10.1093/infdis/141.5.575. [DOI] [PubMed] [Google Scholar]
  10. Powell K. L., Mirkovic R., Courtney R. J. Comparative analysis of polypeptides induced by type 1 and type 2 strains of herpes simplex virus. Intervirology. 1977;8(1):18–29. doi: 10.1159/000148873. [DOI] [PubMed] [Google Scholar]
  11. Royston I., Aurelian L. The association of genital herpesvirus with cervical atypia and carcinoma in situ. Am J Epidemiol. 1970 Jun;91(6):531–538. doi: 10.1093/oxfordjournals.aje.a121164. [DOI] [PubMed] [Google Scholar]
  12. Skare J., Summers W. P., Summers W. C. Structure and function of herpesvirus genomes. I. comparison of five HSV-1 and two HSV-2 strains by cleavage their DNA with eco R I restriction endonuclease. J Virol. 1975 Apr;15(4):726–732. doi: 10.1128/jvi.15.4.726-732.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Smith I. W., Peutherer J. F., Robertson D. H. Virological studies in genital herpes. Lancet. 1976 Nov 13;2(7994):1089–1090. doi: 10.1016/s0140-6736(76)91008-4. [DOI] [PubMed] [Google Scholar]
  14. Warren K. G., Koprowski H., Lonsdale D. M., Brown S. M., Subak-Sharpe J. H. The polypeptide and the DNA restriction enzyme profiles of spontaneous isolates of herpes simplex virus type 1 from explants of human trigeminal, superior cervical and vagus ganglia. J Gen Virol. 1979 Apr;43(1):151–171. doi: 10.1099/0022-1317-43-1-151. [DOI] [PubMed] [Google Scholar]
  15. Wilkie N. M. Physical maps for Herpes simplex virus type 1 DNA for restriction endonucleases Hind III, Hpa-1, and X. bad. J Virol. 1976 Oct;20(1):222–233. doi: 10.1128/jvi.20.1.222-233.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]

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