Abstract
The clinical and microbiological outcome of the treatment of 94 men for uncomplicated non-gonococcal urethritis (NGU) was studied. Rosaramicin 250 mg six hourly for seven days was given to 46 men and tetracycline 250 mg six hourly for seven days to 48 men; the follow-up period was up to six weeks. Complete resolution of the clinical signs of infection was seen in 40 (87%) of the men treated with rosaramicin and in 37(77%) of those treated with tetracycline. Chlamydia trachomatis was eliminated from 17 of the 18 men treated with rosaramicin and from all of the 16 men treated with tetracycline. Ureaplasma urealyticum was eliminated from 12 of the 14 men treated with rosaramicin and from 15 of the 19 receiving tetracycline. Clinical recovery correlated well with the elimination of C trachomatis but less well with that of U urealyticum. The two antimicrobial agents were equally effective in the therapy of NGU, but gastrointestinal side effects were significantly more common in men treated with rosaramicin.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bowie W. R. Etiology and treatment of nongonococcal urethritis. Sex Transm Dis. 1978 Jan-Mar;5(1):27–33. doi: 10.1097/00007435-197801000-00009. [DOI] [PubMed] [Google Scholar]
- Bowie W. R., Yu J. S., Fawcett A., Jones H. D. Tetracycline in nongonococcal urethritis. Comparison of 2 g and 1 g daily for seven days. Br J Vener Dis. 1980 Oct;56(5):332–336. doi: 10.1136/sti.56.5.332. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dacso C., Greenberg S., Martin R. R. Rosaramicin treatment of gonococcal urethritis in men. Sex Transm Dis. 1980 Jul-Sep;7(3):133–134. doi: 10.1097/00007435-198007000-00009. [DOI] [PubMed] [Google Scholar]
- Juvakoski T., Allgulander C., Lassus A. Rosaramicin and tetracycline treatment in Chlamydia trachomatis-positive and -negative nongonococcal urethritis. Sex Transm Dis. 1981 Jan-Mar;8(1):12–15. doi: 10.1097/00007435-198101000-00005. [DOI] [PubMed] [Google Scholar]
- Oriel J. D., Ridgway G. L., Tchamouroff S. Comparison of erythromycin stearate and oxytetracycline in the treatment of non-gonococcal urethritis: their efficacy against Chlamydia trachomatis. Scott Med J. 1977 Dec;22(5):375–379. doi: 10.1177/00369330770220S106. [DOI] [PubMed] [Google Scholar]
- Phillips I., Humphrey D., Middleton A., Nicol C. S. Diagnosis of gonorrhoea by culture on a selective medium containing vancomycin, colistin, nystatin and trimethoprim (VCNT). A comparison with Gram-staining and immunofluorescence. Br J Vener Dis. 1972 Aug;48(4):287–292. doi: 10.1136/sti.48.4.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reeve P., Owen J., Oriel J. D. Laboratory procedures for the isolation of chlamydia trachomatis from the human genital tract. J Clin Pathol. 1975 Nov;28(11):910–914. doi: 10.1136/jcp.28.11.910. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schachter J. Chlamydial infections (first of three parts). N Engl J Med. 1978 Feb 23;298(8):428–435. doi: 10.1056/NEJM197802232980805. [DOI] [PubMed] [Google Scholar]
- Taylor-Robinson D., Addey J. P., Goodwin C. S. Comparison of technics for the isolation of T-strain mycoplasmas. Nature. 1969 Apr 19;222(5190):274–275. doi: 10.1038/222274a0. [DOI] [PubMed] [Google Scholar]
- Taylor-Robinson D., McCormack W. M. The genital mycoplasmas (first of two parts). N Engl J Med. 1980 May 1;302(18):1003–1010. doi: 10.1056/NEJM198005013021805. [DOI] [PubMed] [Google Scholar]
- Willcox R. R. 'Triple tetracycline' in the treatment of non-gonococcal urethritis in males. Br J Vener Dis. 1972 Apr;48(2):137–140. doi: 10.1136/sti.48.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]