Abstract
In a double-blind study the therapeutic efficacy of a single 500-mg clotrimazole pessary was compared with that of a 200-mg clotrimazole pessary inserted once daily for three days in 72 patients with vaginal candidosis confirmed by culture. On clinical assessment four weeks after completion of treatment with the single-dose pessary the cure rate was 86% compared with 92% after the three-day regimen. There was no significant difference in the eradication rate between the single-dose (94%) and three-day regimens (89%). Four weeks after completion of treatment the recurrence rates by culture were 18% with the single-dose and 24% with the three-day regimen. The former treatment was well tolerated and as effective as the three-day clotrimazole regimen.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Higton B. K. A trial of clotrimazole and nystatin in vaginal moniliasis. J Obstet Gynaecol Br Commonw. 1973 Nov;80(11):992–995. doi: 10.1111/j.1471-0528.1973.tb02962.x. [DOI] [PubMed] [Google Scholar]
- Iwata K., Yamaguchi H., Hiratani T. Mode of action of clotrimazole. Sabouraudia. 1973 Jul;11(2):158–166. doi: 10.1080/00362177385190321. [DOI] [PubMed] [Google Scholar]
- Masterton G., Henderson J., Napier I. R., Moffet M. Six-day clotrimazole therapy in vaginal candidosis. Curr Med Res Opin. 1975;3(2):83–88. doi: 10.1185/03007997509113652. [DOI] [PubMed] [Google Scholar]
- Masterton G., Napier I. R., Henderson J. N., Roberts J. E. Three-day clotrimazole treatment in candidal vulvovaginitis. Br J Vener Dis. 1977 Apr;53(2):126–128. doi: 10.1136/sti.53.2.126. [DOI] [PMC free article] [PubMed] [Google Scholar]