Abstract
Consecutive serum samples were obtained from patients with syphilis before and on three occasions after treatment. The sera contained immunosuppresive factors associated with the immunoglobulin fraction, which could depress the natural killer cell activity of healthy controls. There was no evidence that allogeneic or lymphocytotoxic antibodies played a role in immuno-suppression, which could be reproduced with both soluble and insoluble antigen-IgG-antibody complexes.
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Selected References
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- From E., Thestrup-Pedersen K., Thulin H. Reactivity of lymphocytes from patients with syphilis towards T. pallidum antigen in the leucocyte migration and lymphocyte transformation tests. Br J Vener Dis. 1976 Aug;52(4):224–229. doi: 10.1136/sti.52.4.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fulford K. W., Brostoff J. Leucocyte migration and cell-mediated immunity in syphilis. Br J Vener Dis. 1972 Dec;48(6):483–488. doi: 10.1136/sti.48.6.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jensen J. R., From E. Alterations in T lymphocytes and T-lymphocyte subpopulations in patients with syphilis. Br J Vener Dis. 1982 Feb;58(1):18–22. doi: 10.1136/sti.58.1.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jensen J. R., Thestrup-Pedersen K., From E. Natural killer cell activity in syphilis. Arch Dermatol Res. 1982;272(1-2):163–165. doi: 10.1007/BF00510409. [DOI] [PubMed] [Google Scholar]
- Jondal M., Pross H. Surface markers on human b and t lymphocytes. VI. Cytotoxicity against cell lines as a functional marker for lymphocyte subpopulations. Int J Cancer. 1975 Apr 15;15(4):596–605. doi: 10.1002/ijc.2910150409. [DOI] [PubMed] [Google Scholar]
- Kay H. D., Bonnard G. D., West W. H., Herberman R. B. A functional comparison of human Fc-receptor-bearing lymphocytes active in natural cytotoxicity and antibody-dependent cellular cytotoxicity. J Immunol. 1977 Jun;118(6):2058–2066. [PubMed] [Google Scholar]
- Levene G. M., Turk J. L., Wright D. J., Grimble A. G. Reduced lymphocyte transformation due to a plasma factor in patients with active syphilis. Lancet. 1969 Aug 2;2(7614):246–247. doi: 10.1016/s0140-6736(69)90010-5. [DOI] [PubMed] [Google Scholar]
- Moretta L., Mingari M. C., Moretta A., Cooper M. D. Human T lymphocyte subpopulations: studies of the mechanism by which T cells bearing Fc receptors for IgG suppress T-dependent B cell differentiation induced by pokeweed mitogen. J Immunol. 1979 Mar;122(3):984–990. [PubMed] [Google Scholar]
- Rabinovitch M., Manejias R. E., Nussenzweig V. Selective phagocytic paralysis induced by immobilized immune complexes. J Exp Med. 1975 Oct 1;142(4):827–838. doi: 10.1084/jem.142.4.827. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ryan J. L., Arbeit R. D., Dickler H. B., Henkart P. A. Inhibition of lymphocyte mitogenesis by immobilized antigen-antibody complexes. J Exp Med. 1975 Oct 1;142(4):814–826. doi: 10.1084/jem.142.4.814. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sølling J., Sølling K., Jakobsen K. U., From E. Circulating immune complexes in syphilis. Acta Derm Venereol. 1978;58(3):263–267. [PubMed] [Google Scholar]
- West W. H., Cannon G. B., Kay H. D., Bonnard G. D., Herberman R. B. Natural cytotoxic reactivity of human lymphocytes against a myeloid cell line: characterization of effector cells. J Immunol. 1977 Jan;118(1):355–361. [PubMed] [Google Scholar]
- Wicher V., Wicher K. In vitro cell response of Treponema pallidum-infected rabbits. II. Inhibition of lymphocyte response to phytohaemagglutinin by serum of T. pallidum-infected rabbits. Clin Exp Immunol. 1977 Sep;29(3):487–495. [PMC free article] [PubMed] [Google Scholar]
- de Jong N. J., Koehorst J. A., van der Sluis J. J., Boer A. M. Autolymphocytotoxins in syphilis. Br J Vener Dis. 1980 Oct;56(5):297–301. doi: 10.1136/sti.56.5.297. [DOI] [PMC free article] [PubMed] [Google Scholar]