Abstract
Different brands of vaginal tampons varied significantly (p less than 0.0001) in their anti-bacterial effects when tested with 46 strains of Neisseria gonorrhoeae. Gonococcal strains recovered from patients with disseminated infections were substantially more sensitive to the anti-bacterial effects of tampons than were strains from patients with uncomplicated genital infections. Strains from patients with pelvic inflammatory disease were moderately sensitive. Tampons showing strong in-vitro antigonococcal effects were also generally effective in vivo in eliminating gonococcal infections from subcutaneous chambers in mice. Extracts of the Rely tampon showed no in-vitro antigonococcal effect, however, but did induce antibacterial activity when injected into subcutaneous chambers in mice. These results emphasise the importance of both in-vitro as well as in-vivo testing of tampon materials to elucidate more fully the nature of their antibacterial effects and their potential for affecting vaginal pathogens and disease processes.
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Selected References
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- Arko R. J. Neisseria gonorrhoeae: experimental infection of laboratory animals. Science. 1972 Sep 29;177(4055):1200–1201. doi: 10.1126/science.177.4055.1200. [DOI] [PubMed] [Google Scholar]
- Arko R. J., Wong K. H., Finley-Price K. G., Rasheed J. K. Effects of tampon components on growth and dissemination of Neisseria gonorrhoeae. Br J Vener Dis. 1982 Apr;58(2):105–108. doi: 10.1136/sti.58.2.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Arko R. J., Wong K. H., Steurer F. J., Schalla W. O. Complement-enhanced immunity to infection with Neisseria gonorrhoeae in mice. J Infect Dis. 1979 May;139(5):569–574. doi: 10.1093/infdis/139.5.569. [DOI] [PubMed] [Google Scholar]
- Haughie G. E., Ames W. R., Madsen E. F. The use of tampons for identifying asymptomatic N. gonorrhoeae infections. J Am Vener Dis Assoc. 1975 Dec;2(2):26–28. [PubMed] [Google Scholar]
- McCormack W. M., Alpert S., Crockett V. A., Zinner S. H. Evaluation of self-obtained cultures using a vaginal tampon as a method of screening for asymptomatic gonorrhea on a college campus. J Am Vener Dis Assoc. 1974 Dec;1(2):85–87. [PubMed] [Google Scholar]
- McCormack W. M., Lee Y. H., Holtrop H. R., Rychwalski R. Evaluation of the vaginal tampon as a means of obtaining cultures for Neisseria gonorrhoeae. J Infect Dis. 1973 Jul;128(1):129–131. doi: 10.1093/infdis/128.1.129. [DOI] [PubMed] [Google Scholar]
- Shands K. N., Schmid G. P., Dan B. B., Blum D., Guidotti R. J., Hargrett N. T., Anderson R. L., Hill D. L., Broome C. V., Band J. D. Toxic-shock syndrome in menstruating women: association with tampon use and Staphylococcus aureus and clinical features in 52 cases. N Engl J Med. 1980 Dec 18;303(25):1436–1442. doi: 10.1056/NEJM198012183032502. [DOI] [PubMed] [Google Scholar]
- Todd J., Fishaut M., Kapral F., Welch T. Toxic-shock syndrome associated with phage-group-I Staphylococci. Lancet. 1978 Nov 25;2(8100):1116–1118. doi: 10.1016/s0140-6736(78)92274-2. [DOI] [PubMed] [Google Scholar]