Skip to main content
NCBI home page
The British Journal of Venereal Diseases logoLink to The British Journal of Venereal Diseases
. 1984 Feb;60(1):1–7. doi: 10.1136/sti.60.1.1

Studies of rabbit testes infected with Treponema pallidum. III. Immunosuppressive activity of infiltrating mononuclear cells.

V Wicher, K Wicher
PMCID: PMC1046261  PMID: 6230135

Abstract

When mononuclear cells infiltrating rabbit testes infected with Treponema pallidum were cocultured with autologous or homologous peripheral blood lymphocytes spontaneous stimulation and that induced by concanavalin A were suppressed. The inhibition was not due to the cytotoxic effect of the mononuclear cells or to their interference with the active site of concanavalin A (competitive inhibition). The suppressor activity was present in both T and non-T cells but was not affected by pretreatment of the mononuclear cells with indomethacin, a prostaglandin synthetase inhibitor. The suppressor activity may be intrinsic to the mononuclear cells or acquired by the cells in the testicular environment.

Full text

PDF
1

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C. Mechanisms by which activated macrophages inhibit lymphocyte responses. Immunol Rev. 1978;40:3–27. doi: 10.1111/j.1600-065x.1978.tb00399.x. [DOI] [PubMed] [Google Scholar]
  2. Baughn R. E., Musher D. M. Reappraisal of lymphocyte responsiveness to concanavalin A during experimental syphilis: evidence that glycosaminoglycans in the sera and tissues interfere ith active binding sites on the lectin and not with the lymphocytes. Infect Immun. 1982 Feb;35(2):552–559. doi: 10.1128/iai.35.2.552-559.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bey R. F., Johnson R. C., Fitzgerald T. J. Suppression of lymphocyte response to concanavalin A by mucopolysaccharide material from Treponema pallidum-infected rabbits. Infect Immun. 1979 Oct;26(1):64–69. doi: 10.1128/iai.26.1.64-69.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fitzgerald T. J., Johnson R. C. Influence of testicular fluid infected with Treponema pallidum on intradermal lesions. Br J Vener Dis. 1980 Jun;56(3):125–128. doi: 10.1136/sti.56.3.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Laughter A. H., Twomey J. J. Suppression of lymphoproliferation by high concentrations of normal human mononuclear leukocytes. J Immunol. 1977 Jul;119(1):173–179. [PubMed] [Google Scholar]
  6. Lord E. M., Sensabaugh G. F., Stites D. P. Immunosuppressive activity of human seminal plasma. I. Inhibition of in vitro lymphocyte activation. J Immunol. 1977 May;118(5):1704–1711. [PubMed] [Google Scholar]
  7. Marcus Z. H., Freisheim J. H., Houk J. L., Herman J. H., Hess E. V. In vitro studies in reproductive immunology. 1. Suppression of cell-mediated immune response by human spermatozoa and fractions isolated from human seminal plasma. Clin Immunol Immunopathol. 1978 Mar;9(3):318–326. doi: 10.1016/0090-1229(78)90103-4. [DOI] [PubMed] [Google Scholar]
  8. Prakash C., Coutinho A., Möller G. Inhibition of in vitro immune responses by a fraction from seminal plasma. Scand J Immunol. 1976;5(1-2):77–85. doi: 10.1111/j.1365-3083.1976.tb02994.x. [DOI] [PubMed] [Google Scholar]
  9. SCOTT V., DAMMIN G. J. Hyaluronidase and experimental syphilis. III. Metachromasia in syphilitic orchitis and its relationship to hyaluronic acid. Am J Syph Gonorrhea Vener Dis. 1950 Nov;34(6):501–514. [PubMed] [Google Scholar]
  10. TURNER T. B., HOLLANDER D. H. Studies on the mechanism of action of cortisone in experimental syphilis. Am J Syph Gonorrhea Vener Dis. 1954 Sep;38(5):371–387. [PubMed] [Google Scholar]
  11. Trizio D., Cudkowicz G. Separation of T and B lymphocytes by nylon wool columns: evaluation of efficacy by functional assays in vivo. J Immunol. 1974 Oct;113(4):1093–1097. [PubMed] [Google Scholar]
  12. Wicher K., Wicher V., Kaminski D. Effect of Treponema pallidum-infected testis supernatants on the cellular response of normal rabbit lymphocytes. Infect Immun. 1980 Mar;27(3):846–850. doi: 10.1128/iai.27.3.846-850.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Wicher K., Wicher V., Nakeeb S. M., Dubiski S. Studies of rabbit testes infected with Treponema pallidum. I Immunopathology. Br J Vener Dis. 1983 Dec;59(6):349–358. doi: 10.1136/sti.59.6.349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wicher V., Wicher K. In vitro cell response of Treponema pallidum-infected rabbits. II. Inhibition of lymphocyte response to phytohaemagglutinin by serum of T. pallidum-infected rabbits. Clin Exp Immunol. 1977 Sep;29(3):487–495. [PMC free article] [PubMed] [Google Scholar]
  15. Wicher V., Wicher K. Studies of rabbit testes infected with Treponema pallidum. II Local synthesis of antibodies. Br J Vener Dis. 1983 Dec;59(6):359–363. doi: 10.1136/sti.59.6.359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Winchester R. J., Fu S. M. Lymphocyte surface membrane immunoglobulin. Scand J Immunol. 1976 Jun;Suppl 5:77–82. doi: 10.1111/j.1365-3083.1976.tb03858.x. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Venereal Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES