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. 1984 Aug;60(4):231–234. doi: 10.1136/sti.60.4.231

Rosoxacin in the treatment of uncomplicated gonorrhoea in men.

K Panikabutra, C Ariyarit, A Chitwarakorn, C Saensanoh
PMCID: PMC1046315  PMID: 6234966

Abstract

Between 3 January and 4 March 1983 we treated 200 male patients diagnosed as having uncomplicated gonococcal urethritis with one of two regimens. They were divided into two groups and randomly assigned to treatment with either 2 g spectinomycin administered intramuscularly (group A) or 300 mg rosoxacin by mouth (group B). Of 187 isolates tested for the production of beta-lactamase, 101 (54%) were penicillinase producing Neisseria gonorrhoeae (PPNG) strains. All 81 cases followed in group A (spectinomycin) were cured, compared with 88.5% (77 out of 87) of the patients followed in group B (rosoxacin). We concluded that rosoxacin at a dosage of 300 mg administered orally was fairly effective in the treatment of gonococcal urethritis in men caused by both PPNG and non-PPNG strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berg S. W., Kilpatrick M. E., Harrison W. O., McCutchan J. A. Cefoxitin as a single-dose treatment for urethritis caused by penicillinase-producing Neisseria gonorrhoeae. N Engl J Med. 1979 Sep 6;301(10):509–511. doi: 10.1056/NEJM197909063011001. [DOI] [PubMed] [Google Scholar]
  2. Calubiran O. V., Crisologo-Vizconde L. B., Tupasi T. E., Torres C. A., Limson B. M. Treatment of uncomplicated gonorrhoea in women. Comparison of rosoxacin and spectinomycin. Br J Vener Dis. 1982 Aug;58(4):231–235. doi: 10.1136/sti.58.4.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Centers for Disease Control (CDC) Spectinomycin-resistant penicillinase-producing Neisseria gonorrhoeae--California. MMWR Morb Mortal Wkly Rep. 1981 May 22;30(19):221–222. [PubMed] [Google Scholar]
  4. Easmon C. S., Ison C. A., Bellinger C. M., Harris J. W. Emergence of resistance after spectinomycin treatment for gonorrhoea due to beta-lactamase producing strain of Neisseria gonorrhoeae. Br Med J (Clin Res Ed) 1982 May 29;284(6329):1604–1605. doi: 10.1136/bmj.284.6329.1604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Handsfield H. H., Holmes K. K. Treatment of uncomplicated gonorrhea with cefotaxime. Sex Transm Dis. 1981 Jul-Sep;8(3):187–191. doi: 10.1097/00007435-198107000-00003. [DOI] [PubMed] [Google Scholar]
  6. Jaffe H. W., Biddle J. W., Thornsberry C., Johnson R. E., Kaufman R. E., Reynolds G. H., Wiesner P. J. National gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results. N Engl J Med. 1976 Jan 1;294(1):5–9. doi: 10.1056/NEJM197601012940102. [DOI] [PubMed] [Google Scholar]
  7. Jones R. B., Stimson J., Counts G. W., Holmes K. K. Cefoxitin in the treatment of gonorrhea. Sex Transm Dis. 1979 Oct-Dec;6(4):239–242. doi: 10.1097/00007435-197910000-00002. [DOI] [PubMed] [Google Scholar]
  8. Limson B. M., Macasaet R. K. Single oral dose rosoxacin in the treatment of gonorrhoea in males. J Int Med Res. 1982;10(1):42–45. doi: 10.1177/030006058201000109. [DOI] [PubMed] [Google Scholar]
  9. McCormack W. M. Treatment of gonorrhea -- is penicillin passé. N Engl J Med. 1977 Apr 21;296(16):934–936. doi: 10.1056/NEJM197704212961610. [DOI] [PubMed] [Google Scholar]
  10. Panikabutra K., Ariyarit C., Chitwarakorn A., Warnisorn T. Cefotaxime in the treatment of gonorrhoea caused by penicillinase producing N. gonorrhoeae (PPNG) and non penicillinase producing N. gonorrhoeae (Non PPNG). J Med Assoc Thai. 1982 May;65(5):271–276. [PubMed] [Google Scholar]
  11. Panikabutra K., Ariyarit C., Chitwarakorn A., Warnnissorn T., Saensanoh C. Sensitivity to penicillin, thiamphenicol, kanamycin, cefoxitin and spectinomycin of penicillinase-producing Neisseria gonorrhoeae (PPNG) in Bangkok. Relation to the results of treatment. J Med Assoc Thai. 1982 Jun;65(6):316–324. [PubMed] [Google Scholar]
  12. Rajan V. S., Sng E. H., Pang R., Tan N. J., Thirumoorthy T., Yeo K. L. HR 756--a new cephalosporin in the treatment of gonorrhoea caused by ordinary and penicillinase-producing strains of Neisseria gonorrhoeae. Br J Vener Dis. 1980 Aug;56(4):255–258. doi: 10.1136/sti.56.4.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rajan V. S., Sng E. H., Thirumoorthy T., Goh C. L. Ceftriaxone in the treatment of ordinary and penicillinase-producing strains of Neisseria gonorrhoeae. Br J Vener Dis. 1982 Oct;58(5):314–316. doi: 10.1136/sti.58.5.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Seth A. D. Sensitivity of gonococci to rosoxacin compared with that of penicillin, cefuroxime and tetracycline. J Antimicrob Chemother. 1981 Apr;7(4):331–334. doi: 10.1093/jac/7.4.331. [DOI] [PubMed] [Google Scholar]
  15. Siegel M. S., Thompson S. E., Perine P. L., Brown S. T., Reynolds G., Thornsberry C. Treatment of uncomplicated gonococcal urethritis with cefoxitin: comparison with penicillin. Rev Infect Dis. 1979 Jan-Feb;1(1):183–188. doi: 10.1093/clinids/1.1.183. [DOI] [PubMed] [Google Scholar]
  16. Siegel M. S., Thompson S. E., Perine P. L. Penicillinase-producing neisseria gonorrhoeae. Sex Transm Dis. 1977 Jan-Mar;4(1):32–33. [PubMed] [Google Scholar]
  17. Woscoff A., Flichman J. C., Man F., Martinez T. E., de Martinez L. R., Chouela E., Blanzaco D. P. Rosoxacin (Win 35,213) in the treatment of uncomplicated acute gonococcal infection. Clin Ther. 1982;4(6):515–525. [PubMed] [Google Scholar]

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