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. 2023 Aug 11;12:e85647. doi: 10.7554/eLife.85647

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© 2023, Jackson, Giacomassi et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Author response image 1. — (A) BALB/c mice (n=4 per group) received 2x topical ear treatments with 100ug R848, while vehicle mice received 2x treatments with acetone. Ear skin was harvested at 24 hours after the final treatment for transcriptomic analysis. Csf1 transcript counts shown are normalised to a panel of reference genes. Data represent a single experiment. (B) BALB/c mice (n=3 per group) received 100μg of R848 topically or I.P, 3x per week for 4 weeks. Control mice were given topical acetone. Serum CSF-1 levels were quantified by ELISA. Panel (A) was analysed by Mann-Whitney test; panel (B) by oneway ANOVA with Bonferroni’s multiple comparison test versus vehicle group. Data are the mean ± SEM; ns = non significant; p values are indicated.