Table 7.
Coefficients in the fitted mediator and outcome models in the CANTOS trial example
| Mediator model | ||
|---|---|---|
| Estimate | SE | |
| (Intercept) | 0.423 | 0.069 |
| Canakinumab | −0.604 | 0.047 |
| Age | −0.001 | 0.001 |
| Sex (female) | 0.013 | 0.021 |
| Baseline log(hsCRP) | −1.437 | 0.023 |
| Heart failure | 0.093 | 0.019 |
| Hypertension | 0.016 | 0.023 |
| Diabetes | 0.043 | 0.023 |
| Canakinumab×Baseline log(hsCRP) | −0.031 | 0.028 |
| Outcome model | ||
| Estimate | SE | |
| (Intercept) | 7.401 | 0.536 |
| Canakinumab | 0.082 | 0.149 |
| Δ log(hsCRP)a | −0.484 | 0.205 |
| Age | −0.048 | 0.008 |
| Sex (female) | −0.009 | 0.090 |
| Baseline log(hsCRP) | −0.734 | 0.089 |
| Heart failure | −0.639 | 0.082 |
| Hypertension | −0.067 | 0.106 |
| Diabetes | −0.214 | 0.170 |
| Canakinumab×Δ log(hsCRP) | −0.045 | 0.062 |
| Δ log(hsCRP)×Age | 0.004 | 0.003 |
| Δ log(hsCRP)×Diabetes | 0.047 | 0.064 |
a
: Δ log(hsCRP) = log(hsCRP) at month 3 - log(hsCRP) at month 0