Table 4.

Distribution and metabolism profile of natural polymers and native ligand.

Code	Distribution				Metabolism
	PPB	VD	BBB Penetration	Fu (%)	CYP1A2		CYP2C19		CYP2C9		CYP2D6		CYP3A4
					inhibitor	substrate	inhibitor	substrate	inhibitor	substrate	inhibitor	substrate	inhibitor	substrate
NL	93.20	1.28	0.032	2.260	0.068	0.916	0.797	0.828	0.91	0.717	0.062	0.89	0.955	0.927
Agarose	14.59	0.044	0.355	53.72	0.0	0.007	0.011	0.05	0.0	0.005	0.005	0.064	0.004	0.001
Alginate	12.98	0.31	0.407	72.73	0.001	0.009	0.015	0.034	0.001	0.256	0.003	0.092	0.007	0.0
Carrageenan	94.64	0.357	0.374	4.151	0.234	0.543	0.443	0.073	0.76	0.914	0.417	0.736	0.42	0.294
Chitosan	−7.84	−0.872	0.813	67.23	0	0	0	0	0	0	0	0.007	0.007	0
Cyclodextrin	7.042	−1.086	0.792	40.21	0.0	0.0	0.001	0.034	0.0	0.0	0.0	0.015	0.001	0.0
Dextran	8.948	0.152	0.352	60.85	0.0	0.004	0.002	0.039	0.0	0.047	0.0	0.054	0.001	0.0
Hyaluronic acid	7.569	0.226	0.448	67.00	0.0	0.0	0.013	0.023	0.0	0.005	0.001	0.017	0.011	0.0
Polysialic acid	12.22	0.287	0.298	82.89	0.003	0.019	0.017	0.046	0.002	0.063	0.001	0.063	0.011	0.004