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. 2023 Sep 6;621(7977):E7–E26. doi: 10.1038/s41586-023-06355-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, The results of a GWAS analysis of hospitalized individuals with COVID-19 (n = 49,033 cases and n = 3,393,109 controls) (top), and the results for individuals with reported SARS-CoV-2 infection (n = 219,692 cases and n = 3,001,905 controls) (bottom). The loci highlighted in yellow (top) represent regions that are associated with severity of COVID-19. The loci highlighted in green (bottom) are regions associated with susceptibility to SARS-CoV-2 infection. Lead variants for the loci that were identified in this data release are annotated with their respective rsID. The y axis is on the −log₁₀ (P) scale up to 10, after which it switches to a 10 × log₁₀[−log₁₀(P)] scale to aid presentation. b, Results of gene prioritization using different evidence measures of gene annotation. For the genes in a linkage-disequilibrium (LD) region, genes with coding variants and eGenes (fine-mapped cis-expression quantitative trait locus (cis-eQTL) variant with posterior inclusion probability (PIP) >0.1 in GTEx Lung) are annotated as such if they are in linkage disequilibrium with a COVID-19 lead variant (r² > 0.6). V2G, the highest gene prioritized by OpenTargetGenetics V2G score. The pink circle indicates SARS-CoV-2 infection susceptibility, the green triangle indicates COVID-19 severity and the blue cross indicates unclassified. This figure was reproduced from the original publication by the COVID-19 HGI¹ with modifications reflecting the updated analysis from data release 7.