Table 2.

Names, structures, and inhibition constants of cathinones as human 5-HT_2AR ligands compiling the TR.

Name (Number) P (Mechanism) a	Compound’s Structure	pKi	Ref.	Name (Number) P (Mechanism) a	Compound’s Structure	pKi	Ref.
Cathinone and its derivatives				Naphyrone (13) FA		4.96	[34]
Cathinone (1) AG a		6.00	[34]	MDPV (14) FA		4.88	[34]
Flephedrone (2) AG		6.00	[34]	Pyrovalerone (15) FA		4.88	[34]
Mephedrone (3) AG		5.68	[34]	MDPPP (16) FA		4.20	[21]
Methcathinone (4) AG		5.23	[34]	Benzo[d][1,3]dioxole-based SCs
4-Bromomethcathinone (5) IA/FA		5.20	[21]	MDBD (17) AG		5.20	[34]
3-Bromomethcathinone (6) IA/FA		5.00	[21]	MDMA (18) AG		5.11	[34]
2-Fluoromethcathinone (7) IA/FA		5.00	[21]	Butylone (19) AG		4.88	[34]
2-(Trifluoromethoxy) -methcathinone (8) IA/FA		5.00	[21]	Ethylone (20) AG		4.88	[34]
Pyrovalerone-based SCs				MDEA (21) AG		4.88	MDEA AG (21)
α-PPP (9) IA/FA		5.60	[21]	Methylone (22) AG		4.88	[34]
4-Methyl-α-PPP (10) IA/FA		5.50	[21]	SCs ’ precursors
4-Bromo-α-PPP (11) IA/FA		5.40	[21]	Amphetamine (23) AG		4.88	[34]
3-Bromo-α-PPP (12) IA/FA		5.00	[21]	Methamphetamine (24) AG		4.88	[34]

^a Pharmacology: AG—agonist, IA—inverse agonist, PA—partial agonist, FA—full antagonist.