Skip to main content
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1983 Feb;20(1):37–40. doi: 10.1136/jmg.20.1.37

Acetylator phenotypes in Papua New Guinea

R J A Penketh *, S F A Gibney , G T Nurse , D A Hopkinson
PMCID: PMC1048983  PMID: 6842533

Abstract

Acetylator phenotypes have been determined in 139 unrelated subjects from the hitherto untested populations of Papua New Guinea, and their relevance to current antituberculous isoniazid chemotherapy is discussed.

Full text

PDF
37

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Batchelor J. R., Welsh K. I., Tinoco R. M., Dollery C. T., Hughes G. R., Bernstein R., Ryan P., Naish P. F., Aber G. M., Bing R. F. Hydralazine-induced systemic lupus erythematosus: influence of HLA-DR and sex on susceptibility. Lancet. 1980 May 24;1(8178):1107–1109. doi: 10.1016/s0140-6736(80)91554-8. [DOI] [PubMed] [Google Scholar]
  2. DEVADATTA S., GANGADHARAM P. R., ANDREWS R. H., FOX W., RAMAKRISHNAN C. V., SELKON J. B., VELU S. Peripheral neuritis due to isoniazid. Bull World Health Organ. 1960;23:587–598. [PMC free article] [PubMed] [Google Scholar]
  3. Ellard G. A. Variations between individuals and populations in the acetylation of isoniazid and its significance for the treatment of pulmonary tuberculosis. Clin Pharmacol Ther. 1976 May;19(5 Pt 2):610–625. doi: 10.1002/cpt1976195part2610. [DOI] [PubMed] [Google Scholar]
  4. Evans D. A. An improved and simplified method of detecting the acetylator phenotype. J Med Genet. 1969 Dec;6(4):405–407. doi: 10.1136/jmg.6.4.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Karim A. K., Elfellah M. S., Evans D. A. Human acetylator polymorphism: estimate of allele frequency in Libya and details of global distribution. J Med Genet. 1981 Oct;18(5):325–330. doi: 10.1136/jmg.18.5.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. McLoughlin K., Blake N. M., Hogan P. F. Blood group, red cell enzyme and serum protein types in the Buka Islanders, Papua New Guinea. Hum Hered. 1982;32(3):152–159. doi: 10.1159/000153280. [DOI] [PubMed] [Google Scholar]
  7. Weber W. W., Hein D. W. Clinical pharmacokinetics of isoniazid. Clin Pharmacokinet. 1979 Nov-Dec;4(6):401–422. doi: 10.2165/00003088-197904060-00001. [DOI] [PubMed] [Google Scholar]
  8. Woosley R. L., Drayer D. E., Reidenberg M. M., Nies A. S., Carr K., Oates J. A. Effect of acetylator phenotype on the rate at which procainamide induces antinuclear antibodies and the lupus syndrome. N Engl J Med. 1978 May 25;298(21):1157–1159. doi: 10.1056/NEJM197805252982101. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES