Skip to main content
NCBI home page
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1983 Feb;20(1):41–45. doi: 10.1136/jmg.20.1.41

Immunological tolerance induced by in utero injection.

R D Barnes, B E Pottinger, J Marston, P Flecknell, R H Ward, S Kalter, R L Heberling
PMCID: PMC1048984  PMID: 6341592

Abstract

Intrauterine injection of human whole blood into rabbit and rhesus monkey fetuses was found to result in long lasting unresponsiveness to human serum albumin. Intrauterine injection of viable allogeneic bone marrow cells into rabbit fetuses was without any apparent harmful effect and also resulted in permanent unresponsiveness demonstrated by donor red cell survival studies. The implication of these findings in respect of using this approach towards the correction of certain inherited diseases in man is discussed.

Full text

PDF
41

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BILLINGHAM R. E., BRENT L. A simple method for inducing tolerance of skin homografts in mice. Transplant Bull. 1957 Apr;4(2):67–71. [PubMed] [Google Scholar]
  2. BILLINGHAM R. E., BRENT L., MEDAWAR P. B. Actively acquired tolerance of foreign cells. Nature. 1953 Oct 3;172(4379):603–606. doi: 10.1038/172603a0. [DOI] [PubMed] [Google Scholar]
  3. Barnes R. D. The use of early embryo aggregation derived mouse chimaeras. II. The study of disease processes. J Immunogenet. 1976 Dec;3(6):411–421. doi: 10.1111/j.1744-313x.1976.tb00603.x. [DOI] [PubMed] [Google Scholar]
  4. Barnes R. D. Tolerance in early embryo aggregation (EEA) derived mouse chimeras. Transplant Proc. 1976 Sep;8(3):359–362. [PubMed] [Google Scholar]
  5. CINADER B., DUBERT J. M. Acquired immune tolerance to human albumin and the response to subsequent injections of diazo human albumin. Br J Exp Pathol. 1955 Oct;36(5):515–529. [PMC free article] [PubMed] [Google Scholar]
  6. CINADER B., DUBERT J. M. Specific inhibition of response to purified protein antigens. Proc R Soc Lond B Biol Sci. 1956 Nov 13;146(922):18–33. doi: 10.1098/rspb.1956.0068. [DOI] [PubMed] [Google Scholar]
  7. Cotes P. M., Hobbs K. R., Bangham D. R. Development of the immune response in the foetal and newborn rhesus monkey. I. Response to bovine serum albumin. Immunology. 1966 Sep;11(3):185–198. [PMC free article] [PubMed] [Google Scholar]
  8. DIXON F. J., MAUER P. H. Immunologic unresponsiveness induced by protein antigens. J Exp Med. 1955 Mar 1;101(3):245–257. doi: 10.1084/jem.101.3.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DIXON F. J., MAURER P. H. Fate of antibody following in vivo combination with specific antigen. Proc Soc Exp Biol Med. 1953 Nov;84(2):442–446. doi: 10.3181/00379727-84-20672. [DOI] [PubMed] [Google Scholar]
  10. DRAY S. Effect of maternal isoantibodies on the quantitative expression of two allelic genes controlling gamma-globulin allotypic specificities. Nature. 1962 Aug 18;195:677–680. doi: 10.1038/195677a0. [DOI] [PubMed] [Google Scholar]
  11. Fairweather D. V., Ward R. H., Modell B. Obstetric aspects of midtrimester fetal blood sampling by needling or fetoscopy. Br J Obstet Gynaecol. 1980 Feb;87(2):87–99. doi: 10.1111/j.1471-0528.1980.tb04499.x. [DOI] [PubMed] [Google Scholar]
  12. HANAN R., OYAMA J. Inhibition of antibody formation in mature rabbits by contact with the antigen at an early age. J Immunol. 1954 Jul;73(1):49–53. [PubMed] [Google Scholar]
  13. HASEK M., HRABA T. Immunological effects of experimental embryonal parabiosis. Nature. 1955 Apr 30;175(4461):764–765. doi: 10.1038/175764a0. [DOI] [PubMed] [Google Scholar]
  14. HUMPHREY J. H. IMMUNOLOGICAL UNRESPONSIVENESS TO PROTEIN ANTIGENS IN RABBITS. II. THE NATURE OF THE SUBSEQUENT ANTIBODY RESPONSE. Immunology. 1964 Jul;7:462–473. [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES