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. 1983 Feb;20(1):69–72. doi: 10.1136/jmg.20.1.69

Monosomy 22 with humoral immunodeficiency: is there an immunoglobulin chain deficit?

J L García Miranda, A Otero Gómez, H Varela Ansedes, N Rancel Torres, C González Espinosa, C Cortabarría, G Sánchez Salgado
PMCID: PMC1048992  PMID: 6842539

Abstract

The cytogenetic analysis of a patient with selective deficit of IgA and decrease in IgM, IgE, and IgG is presented. Using trypsin-Giemsa banding the karyotype showed monosomy 22 (45,XX,-22). The interest of this case lies in the rarity of the illness and in the association of monosomy 22 with hypogammaglobulinaemia and selective deficit of IgA, particularly as this chromosome is known to contain genes coding for immunoglobulin chains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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