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Oral glucose tolerance test in 6- and 10-month-old mice on STD and HFD. Time course of OGTT after orally administered glucose at a dose 2 g/kg at 6 months (A) and 10 months (B) of age and area under curve (AUC) (C). The data are presented as the means ± SD. Statistical analysis was made by one-way ANOVA with Bonferroni post hoc test (n = 5–12 mice per group). The significance of changes induced by diet: ***: p < 0.001, by genotype: ##: p < 0.01, ###: p < 0.001.
