Abstract
Hypostatic leg ulcers, probably secondary to vascular insufficiency, were observed in two adult men with 47,XXY Klinefelter's syndrome. The association between leg ulcers and 47,XXY Klinefelter's syndrome deserves increased attention because knowledge of the association may alert clinicians to an otherwise unsuspected chromosome abnormality.
Full text
PDF

Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Andersen K. E. Sex chromosomal anomalies: a possible association with leg ulcers. Clin Exp Dermatol. 1979 Jun;4(2):223–226. doi: 10.1111/j.1365-2230.1979.tb01622.x. [DOI] [PubMed] [Google Scholar]
- Fricke G. R., Mattern H. J., Schweikert H. U. Mitral valve prolapse in Klinefelter syndrome. Lancet. 1981 Dec 19;2(8260-61):1414–1414. doi: 10.1016/s0140-6736(81)92821-x. [DOI] [PubMed] [Google Scholar]
- Howell R. Hypostatic ulceration and Klinefelter's syndrome. Br Med J. 1978 Jul 8;2(6130):95–96. doi: 10.1136/bmj.2.6130.95-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Matin M. A., Sylvester P. E. Clinicopathological studies of oculo cerebrorenal syndrome of Lowe, Terrey and MacLachlan. J Ment Defic Res. 1980 Mar;24(1):1–16. doi: 10.1111/j.1365-2788.1980.tb00052.x. [DOI] [PubMed] [Google Scholar]
- Raso A. M., Ressa P. G., Levis P., Colombo R. Peculiaridad de las úlceras de los miembros inferiores en el sindrome de Klinefelter. Angiologia. 1980 Sep-Oct;32(5):197–204. [PubMed] [Google Scholar]
- Vogt H. J., Breit R. Ulcus cruris als Symptom eines Klinefelter-Syndroms. Hautarzt. 1969 Oct;20(10):468–469. [PubMed] [Google Scholar]
- Zuppinger K., Engel E., Forbes A. P., Mantooth L., Claffey J. Klinefelter's syndrome, a clinical and cytogenetic study in twenty-four cases. Acta Endocrinol (Copenh) 1967;54(Suppl):5+–5+. doi: 10.1530/acta.0.054s005. [DOI] [PubMed] [Google Scholar]