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Potential impacts and interactions of aspartame and its metabolites on known autism risk factors. (OCM: one-carbon metabolism, including the transsulfuration pathway, methionine cycle, and folate cycle; GSH: reduced glutathione, a major antioxidant involved in defense against oxidative stress; detoxification; maintenance of methylation capacity; SAM: S-adenosylmethionine, the major methyl donor for cellular methylation processes; BBB: blood–brain barrier).
