Skip to main content
PLOS ONE logoLink to PLOS ONE
. 2023 Sep 8;18(9):e0291490. doi: 10.1371/journal.pone.0291490

Retraction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

The PLOS ONE Editors
PMCID: PMC10490959  PMID: 37682814

Following the publication of this article [1, 2], concerns were raised with results presented in Fig 1. Specifically:

  • The S6K panel in Fig 1F of [1] appears similar to the Fig 2A U87PTEN actin panel published in [3].

  • The AKT panel in Fig 1F of [1] appears similar to the Fig 2A U87PTEN p-AKT panel published in [3] when horizontally flipped.

The corresponding author commented that the above concerns were the result of errors made during figure preparation and stated that the underlying data for these panels are no longer available. In the absence of the original data underlying the published results these issues cannot be resolved. The corresponding author regrets any inconvenience to the scientific community that may have occurred, and requested the retraction of the article.

In light of the unresolved concerns with Fig 1 that question the reliability of these results, the PLOS ONE Editors retract this article.

MEJ and JG agree with retraction. ABS, JL, BH, KAL, TB, and AL either did not respond directly or could not be reached.

References

  • 1.Benavides-Serrato A, Lee J, Holmes B, Landon KA, Bashir T, Jung ME, et al. (2017) Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma. PLoS ONE 12(4): e0176599. doi: 10.1371/journal.pone.0176599 [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]
  • 2.Benavides-Serrato A, Lee J, Holmes B, Landon KA, Bashir T, Jung ME, et al. (2019) Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma. PLoS ONE 14(2): e0212160. doi: 10.1371/journal.pone.0212160 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Cloninger C, Bernath A, Bashir T, Holmes B, Artinian N, Ruegg T, Anderson L, Masri J, Lichtenstein A, Gera J. Inhibition of SAPK2/p38 enhances sensitivity to mTORC1 inhibition by blocking IRES-mediated translation initiation in glioblastoma. Mol Cancer Ther. 2011. Dec;10(12):2244–56. doi: 10.1158/1535-7163.MCT-11-0478 Epub 2011 Sep 12. ; PMCID: PMC3237929. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from PLOS ONE are provided here courtesy of PLOS

RESOURCES