Abstract
An infant with mosaic trisomy 13, who was small for gestational age, became severely hypoglycaemic. For the first 19 days of life, glucose requirements to maintain normoglycaemia were high (up to 21.7 mg/kg/min) and at the same time the infant had high plasma insulin levels and low glucose insulin ratios. Treatment with hydrocortisone and susphrine was of questionable benefit. Hyperinsulinism abated by the third week of life. This case illustrates early remission of hyperinsulinaemic hypoglycaemia and raises the possibility of an association with trisomy 13.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Joly J. G., Leduc J., Bernier J., Lavoie P., Viallet A. Catecholamine levels in portal, hepatic, and systemic venous blood in portal hypertension. Lancet. 1967 Jul 15;2(7507):121–123. doi: 10.1016/s0140-6736(67)92962-5. [DOI] [PubMed] [Google Scholar]
- Mayer T., Matlak M. E., Lowry S. F., Gooch W. M., 3rd, Johnson D. G. Protean manifestations of neonatal hyperinsulinism. Ann Surg. 1981 Aug;194(2):140–145. doi: 10.1097/00000658-198108000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nagel J. W., Sims J. S., Aplin C. E., 2nd, Westmark E. R. Refractory hypoglycemia associated with a malpositioned umbilical artery catheter. Pediatrics. 1979 Sep;64(3):315–317. [PubMed] [Google Scholar]
- Pinkerton P. H., Cohen M. M. Persistence of hemoglobin F in D/D translocation with trisomy 13-15 (D1). JAMA. 1967 May 15;200(7):647–649. [PubMed] [Google Scholar]